Effect of cow’s milk infant formula on neurodevelopment and growth in infants

The intervention products are infant formula for 0-6 month-old infants and follow-on formula for 6-12 month-old infants. All products comply with GB standard for nutritional composition. Healthy term infants in group 1 receive a infant formula and follow-on formula enriched in complex milk lipids to match the upper end of breast milk levels. Composition of the infant formula products for group 1 per 100 mL of reconstituted powder formula (67 kcal/100 mL): Protein 1.7 g, fat 3.4 g, carbohydrate (lactose) 7.4 g, linoleic acid 400 mg, a-linolenic acid 45 mg, prebiotic, probiotic, vitamins and minerals. Composition of the follow-on formula products for group 1 per 100 kcal of reconstituted powder formula (68 kcal/100 mL): Protein 2.2 g, fat 3.2 g, carbohydrate (lactose) 7.8 g, linoleic acid 360 mg, prebiotic, probiotic, vitamins and minerals. Up to 2 weeks of age, infants will be fed 7-8 times 60 mL of formula by their parent or caregiver at home. Up to 4 weeks of age, infants will be fed 7-8 times 90 mL of formula by their parent or caregiver at home. Up to 2 months of age, infants will be fed 6-7 times 120 mL of formula by their parent or caregiver at home. Up to 4 months of age, infants will be fed 5-6 times 150 mL of formula by their parent or caregiver at home. Up to 6 months of age, infants will be fed 5-6 times 180 mL of formula by their parent or caregiver at home. Between 6 and 12 months of age, infants will be fed 3-4 times 210 mL of formula by their parent or caregiver at home. It is expected that weaning foods will be introduced from 6 months. All infant feeding will be monitored by every scheduled visit, we also will collect and record number of empty cans of formula milk from each infant’s parent throughout the trial.