The Effect of Regional Anesthesia Type on Fetal Well-being During Cesarean Section

The Effect of Epidural Anesthesia and Spinal Anesthesia on Fetal Oxidative Stress During Cesarean Section

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12616001547437

Enrollment

Registered

2016-11-09

Start date

2016-03-15

Completion date

2016-07-25

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In cesarean section operations for determination of anesthesia method besides the patient’s and the doctor’s preference, fetal condition is also important. Oxidative and antioxidative defense systems of body are in a balance normally. Situations in which an imbalance in favor of oxidative damage occurs are associated with serious disorders in newborn. Spinal anesthesia is the most widely used regional anesthesia method for cesarean section, leading to both increased sensitivity of newborn to oxidative stress and also increased maternal free oxygen radicals, and is the method which leads to uteroplacental hypoperfusion by causing hypotension and bradycardia and to increased ephedrine need. During epidural anesthesia complications like hypotension are less encountered and are less serious The aim of our study is the comparison of the effect of spinal anesthesia on newborn fetal oxidative stress during elective cesarean section of parturients with normal pregnancy versus the effect of epidural anesthesia. For this aim Total Antioxidative Status (TAS), Total Oxidative Status (TOS), nitric oxide (NO) level obtained from blood sample taken from umbilical artery after clamping umbilical cord, arterial blood gas will be analysed.and 1st and 5th minute APGAR scores of the newborn will be assessed by a newborn pediatrician blind to the anesthesia type.

Interventions

Epidural anesthesia (18G Touhy needle, 20G epidural catheter,12 mL of total 20 mL solution prepared with 15 mL 0.5%w/v bupivacaine and 2 mL(100 micrograms) phentanyl) Operation will be started after anesthesia level reaches T6 All of the procedure will be applied by an anaesthesiologist in operation room

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

term pregnancy (37-40 weeks) normal pregnancy between 18 and 40 years non smokers non diabetes mellitus and hypertension

Exclusion criteria

emergency cesarean section, those who used drugs except iron supplements and those who smoked during pregnancy, those with complications of pregnancy, those who were diagnosed with intrauterine growth retardation and fetal malformation

Outcome results