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The impact of sex hormones on one-session cognitive therapy for women with spider phobia. .

The impact of estradiol on cognitive reappraisal in women with spider phobia.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12616001525471
Enrollment
62
Registered
2016-11-07
Start date
2016-11-09
Completion date
2017-07-06
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Women are 2-3 times more likely to have an anxiety disorders compared to men. One proposed biological reason for this difference is that changes in sex hormones, particularly, estrogen impact treatment efficacy. The aim of this study is to assess whether sex hormones, particularly estrogen, impact a single-session cognitive intervention for women with spider phobia. Naturally cycling women with spider phobia will receive a one-session cognitive intervention for spider phobia. Outcome measures (scores on the BAT and SPQ, conviction ratings and diagnostic criteria) will be compared for women with high estradiol levels (the main estrogen derivative) versus low estradiol levels as determined by blood serum levels. It is hypothesised that women with high estradaiol levels will have better treatment outcomes compared to women with low estradiol levels.

Interventions

One-session cognitive intervention One-session cognitive intervention for spider phobia is a brief intervention, delivered in a single session and taking between 30-45-mins. It begins with a description of the cognitive model. The relationship between thinking and feeling is demonstrated using an example of a women hearing a loud noise in the night. Participants are provided with a thought monitoring form that consists of three columns: situation (A); belief (B) and consequence (C). With the cl

One-session cognitive intervention One-session cognitive intervention for spider phobia is a brief intervention, delivered in a single session and taking between 30-45-mins. It begins with a description of the cognitive model. The relationship between thinking and feeling is demonstrated using an example of a women hearing a loud noise in the night. Participants are provided with a thought monitoring form that consists of three columns: situation (A); belief (B) and consequence (C). With the clinicians assistance participants complete the form demonstrating that emotional and behavioural consequences (column C) are dependent on beliefs (column B) in any given situation. Participants that demonstrate a lack of understanding regarding the relationship between thinking and feeling are provided with another example. Using the same form catastrophic beliefs regarding spiders are then identified (e.g., what goes through your head when you see a live spider? How do you feel and what do you do?) and challenged using cognitive challenging techniques. To assist in challenging beliefs participants are given a Spider Fact Sheet, which contains factual information about spiders, their behaviour and the level of threat they pose to humans. A clinical psychologist with 8 years experience in providing cognitive-behavioural therapy to people with anxiety disorders will deliver the intervention face to face to each participant individually. Participants will receive the intervention at the UNSW Psychology Clinic. A clinical psychologist that is blind to the participants’ group and independent from the study will assess intervention adherence via video recordings of the sessions. Feedback regarding good adherence or failure to adhere to the intervention protocol will be provided to maintain or improve fidelity.

Sponsors

The University of New South Walkes
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Intervention model
Other
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 35 Years
Healthy volunteers
No

Inclusion criteria

Naturally cycling women with spider phobia, aged 18-35

Exclusion criteria

Pregnant, breastfeeding, using hormonal contraceptives, irregular menstrual cycles, endocrinology disorders, psychosis, physical conditions that may be exacerbated by stress (asthma, heart disease)

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026