None listed
Conditions
Brief summary
European beverage manufacturers are permitted to use health claims when fructose partially replaces sucrose on the basis that fructose raises blood sugars to a lesser extent when sucrose is fully exchanged for fructose. However, the claim relates to a one-third to two-third ratio of fructose:sucrose as being effective without confirmatory evidence. Additionally, fructose has the potential to acutely raise blood pressure and plasma uric acid, which would be regarded as undesirable effects. Hence the aim of this work is to test the glycaemic, uricaemic and blood pressure raising potential of sweetened beverages containing sucrose and fructose added in various proportions to test beverages. Our hypotheses are that partial replacement of sucrose with fructose will lower postprandial glycemic response and raise uricaemia with no effect on blood pressure.
Interventions
This will be a randomised crossover study involving five visits on five days. On two days, 12 healthy adults will receive beverages sweetened with 50g sucrose (duplicate control). On three days participants will receive beverages sweetened with 16.7g fructose + 33.3g sucrose; 25g fructose + 25g sucrose; and 33.3g fructose + 16.7g sucrose. Beverages will be consumed on mornings after an overnight fast. The order that the beverages are given will be randomised to each participant. Blood will be sa
This will be a randomised crossover study involving five visits on five days. On two days, 12 healthy adults will receive beverages sweetened with 50g sucrose (duplicate control). On three days participants will receive beverages sweetened with 16.7g fructose + 33.3g sucrose; 25g fructose + 25g sucrose; and 33.3g fructose + 16.7g sucrose. Beverages will be consumed on mornings after an overnight fast. The order that the beverages are given will be randomised to each participant. Blood will be sampled via cannula by a registered nurse at intervals over two-hours following consumption of the beverages. The washout will be 2-7 days between treatments. All beverages will be given under supervision to ensure they are fully consumed. The study will be run by a MSc student in Human Nutrition under the supervision of a senior lecturer in the University of Otago Clinic Rooms.
Sponsors
University of Otago
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Participants will be normoglycemic male and female adults aged between 18 and 60y inclusive.
Exclusion criteria
Diagnosis of diabetes mellitus, cardiovascular disease, cancer, diseases of the digestive system; pregnant, known food allergies or taking medication that affects glucose absorption and metabolism.
Outcome results
None listed