None listed
Conditions
Brief summary
Thick epicardial fat is a cardiovascular risk factor, and it has been shown to be correlated with obstructive sleep apnea (OSA), coronary artery disease, obesity, metabolic syndrome, and diabetes mellitus. In this study, we aimed to investigate the relation of epicardial fat thickness (EFT) with severity of OSA, clinical and polysomnographic parameters, and to determine independent predictors for EFT. A total of 84 patients with a body mass index <30, and suspected sleep disordered breathing were included in the study. Their EFT were measured using echocardiography. The patients with an apnea-hypopnea index (AHI) <5 were regarded as the controls, the ones with an AHI >5 were included in the study group, and two groups were compared for EFT. The correlations of EFT with polysomnographic and clinical data, and severity of OSA were investigated. A multivariate regression analysis was performed to determine independent predictors for EFT. There were 62 and 22 patients in study and control groups, respectively. Mean EFT was 3.75 +/- 1.07 mm in study, and 2.97 +/- 0.62 mm in the control groups (p<0.001). There was a significant positive correlation of EFT with AHI, oxygen desaturation index 3 (ODI3), and the minimum oxygen saturation as well as with age, body mass index, and neck and waist circumferences. Epicardial fat was significantly thicker in severe OSA patients. ODI3 was an independent predictor for EFT. Non-obese OSA patients have thicker epicardial fat when compared to the controls. ODI3 has a strong correlation with EFT, and it is an independent predictor for it.
Interventions
Participants attend a sleep laboratory for a single night of assessment, during which polysomnography is carried out involving the attachment of sensors to the head and face to assess sleep parameters. Echocardiography is then performed the following morning, which involves holding a small ultrasound device against the chest
Sponsors
Sabri Koseoglu
Eligibility
Sex/Gender
All
Age
19 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
The patients with an apnea-hypopnea index (AHI) <5 were regarded as the controls, the ones with an AHI >5 were included in the study group, and two groups were compared for EFT. Also, all participants have one of the sleep disordered breathing symptoms such as snoring, apnea and daytime sleepiness.
Exclusion criteria
The patients and control groups with BMI more than 30, the ones with hypo/hyperthyroidism, primary heart disease, chronic obstructive or restrictive pulmonary disease, uncontrolled hypertension, craniofacial abnormalities, as well as the smokers and the ones that used hypnotic drugs were excluded.
Outcome results
None listed