None listed
Conditions
Brief summary
Alcohol-removed wines are relevant to reducing the risk of DNA damage and other alcohol-related pathologies in (i) the foetus in utero and the mother/father for those couples who choose to continue drinking wine before and during pregnancy, (ii) those who habitually exceed current alcohol drinking recommendations and are trying to maintain their social habits, (iii) those who are genetically susceptible because they can not metabolise alcohol properly and/or detoxify its carcinogenic metabolite acetaldehyde (i.e. ALDH2 defect commonly found in Asians), (iv) those who want the health benefit of increased wine phenolic intake without the detrimental effect of alcohol in wine or the high sugar in grape juice (e.g. diabetics) and (vi) those who want to drink wine phenolics because of the emerging evidence of their protective effects against neurodegeneration and their role as potential caloric restriction mimetics. The direct benefits of de-alcoholised wine may be particularly relevant to obese individuals because they exhibit higher levels of DNA damage and oxidative stress as well as being at a higher risk of developing diseases associated with increased DNA damage such as cancer, cardiovascular disease and neurodegenerative disorders such as Alzheimer’s disease. The main aim of the project is to test whether daily consumption of either 187.5 ml of Eden Vale de-alcoholised Shiraz for 8 weeks followed by consumption of 375.0ml for another 8 weeks prevents age-associated genome pathology and metabolic stress in overweight/obese men and women who are at least 50 years old. The hypothesis we are testing is “Increased consumption of de-alcoholised red wine prevents DNA damage and other biomarkers of ageing in overweight/obese older men and women”.
Interventions
The aim of the project is to test whether daily consumption of de-alcoholised Shiraz red wine improves indicators of healthy ageing in overweight/obese men and women who are at least 50 years old. The intervention will be conducted over a period of 16 weeks and will test two doses of wine (187.5ml and 375.0ml daily). In the first eight weeks, participants will drink 187.5ml wine daily. Then the same participants will drink 375.0ml in the next eight weeks. The participants will be required to pro
The aim of the project is to test whether daily consumption of de-alcoholised Shiraz red wine improves indicators of healthy ageing in overweight/obese men and women who are at least 50 years old. The intervention will be conducted over a period of 16 weeks and will test two doses of wine (187.5ml and 375.0ml daily). In the first eight weeks, participants will drink 187.5ml wine daily. Then the same participants will drink 375.0ml in the next eight weeks. The participants will be required to provide blood samples at the start of trial, after 8 weeks and at the end of 16 weeks. The effects of the de-alcoholised red wine will be compared to that of drinking water only. Participants will be randomly allocated to either consume the de-alcoholised wine or water. Blood, saliva and cells from the inside of the mouth will be collected on six occasions during the intervention. The tissue samples will be used to determine molecular biomarkers of ageing. Cognitive function and blood pressure will also be measured. After every 4 weeks, the participants will submit the proof of empty bottles electronically.
Sponsors
CSIRO Health and Biosecurity
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Overweight or obese with a BMI 25-35 Kg/m2 Men and women aged 50 years or older Healthy (no sign of any underlying disease such as diabetes)
Exclusion criteria
Current history of therapy for cardiovascular disease, blood pressure, diabetes, cancer, dementia or other life-threatening diseases who are smokers who regularly consume supplements rich in polyphenols
Outcome results
None listed