None listed
Conditions
Brief summary
In this prospective observational study, we are investigating the association between blood proteins (beta-2-glycoprotein I, Apo B100 and HDL) and coronary artery disease as well as complications after percutaneous coronary intervention (stenting or ballooning) and late graft failure after coronary artery bypass grafting.
Interventions
1. To investigate the association between post translational forms of circulating plasma lipoproteins, beta-2-glycoprotein I, HDL and ApoB100, and atherosclerotic coronary disease. 2. To investigate the association between post translational forms of circulating plasma lipoproteins, beta-2-glycoprotein I, HDL and ApoB100, and clinical presentation with atherothrombotic acute coronary disease. 3. To investigate the association between post translational forms of circulating plasma lipoproteins, beta-2-glycoprotein I, HDL and ApoB100, and complications after percutaneous coronary intervention and late graft failure after CABG. The patients having angiography or CT angiography, a 15 ml blood sample shall be collected at the time of procedure. Out of this group, the patients who did not have ACS and have stent implantation shall have second blood sample 3 hours post procedure. The patients presenting with ST elevation myocardial infarction will have collection of only one blood sample 24 hours after the stent implantation. Clinical follow up shall be performed by phone interview at 30 days 12 months and at 2 years.
Sponsors
Eligibility
Inclusion criteria
All patients recommended to have CT coronary angiography or coronary angiography will be recruited. Pre specified subgroup analysis will be performed based upon angiographic findings and clinical presentation. Willing to provide informed consent.
Exclusion criteria
1. Severe valvular disease. 2. Thrombolysis in last one week 3. Previously enrolled in this study 4. Active sepsis 5. Nephrotic syndrome 6. End stage renal failure on dialysis 7. Severe liver disease (Child-Pugh C) 8. Current pregnancy 9. Previously documented Antiphospholipid Antibody Syndrome 10. Active malignancy 11. Cerebrovascular accident in the last 3 months