A Comparative Study of Clonidine and Magnesium sulfate Premedication on peri operative hormonal stress responses, hemodynamic stability and postoperative analgesia in Laparoscopic Cholecystectomy

A comparative study of clonidine and magnesium sulfate premedication on peri operative hormonal stress responses, hemodynamic stability and postoperative analgesia in patients with gallbladder diseases undergoing laparoscopic cholecystectomy: A randomized, double-blind, controlled study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12616001233415

Acronym

C . Vs. Mgso4 in LC

Enrollment

105

Registered

2016-09-05

Start date

2016-01-10

Completion date

2017-01-01

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We will compare preoperative administration of I.V. clonidine and magnesium sulphate in laparoscopic cholecystectomy on stress hormones( cortisol and ACTH levels) , hemdynamic stability and post operative analgesia.

Interventions

3 groups are included in which a total volume of 50 ml . Isotonic saline (0.9%) are given slow intravenous (I.v) infusion over 15 minutes before induction of general anesthesia Group 1: received 1.5 ug/kg of clonidine in the infusion regimen Group 2: received 30 mg/kg of Magnesium sulfate in the infusion Group 3: received saline only(placebo group) infusion of 50 ml. saline

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

American society of A nesthesiologists( ASA) I and II, patients with gallbladder diseases subjected for elective laparoscopic cholecystectomy( LC) .

Exclusion criteria

Patients with cardiovascular,respiratory,renal, hepatic or neurological diseases, diabetes mellitus, pregnancy or breast feeding females, morbidly obese patients, endocrine disorders,prolonged procedures ( more than 120 minutes), patients on anti hypertensives, antipsychotics, analgesics or sedative medications

Outcome results