None listed
Conditions
Brief summary
Purpose: To search platelet activation via detecting three important platelet activation parameters; Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), and Plateletcrit (PCT) in patients with ocular Behcet's disease (BD) in comparison to those in healthy adults as controls. Design: A prospective case control study Participants and Controls: Twenty-five patients within the active period of the ocular BD with posterior segment involvement (Group 1), 25 patients within the inactive period of the ocular BD with posterior segment involvement (Group 2) and 25 age-and sex-matched healthy controls will included into the study (Group 3). Methods: All patients and control subjects will undergo complete ophthalmologic evaluation. MPV, PDW, and PCT will measure in the studied groups. Main Outcome Measures: Alterations in platelet activation parameters. Results: The mean level of MPV value in Group 1, in Group 2, and in Group 3 will determined. Mean serum level of PDW in three groups will determined. Mean serum PCT value in Group 1, in Group 2, and in Group 3 will determined. MPV, PDW, and PCT levels can be significantly altered in ocular BD patients. Conclusion: Platelet activation reflected by MPV, PDW, and PCT may have an impact on the genesis of vessel occlusion in ocular BD with posterior segment involvement. The results may be important for the clinical management of patients with ocular BD in everyday clinical practice since those platelet parameters are routinely detected in complete blood count analyses.
Interventions
Blood sampled will be collected in patients with inactive and active stage of Behcet disease. Patients with active disease will be treated with conventional therapy. Duration of observation is 1 month.
Sponsors
SB Ankara Ulucanlar Eye Education and Research Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
We included the active ocular Behcet’s disease (BD) patients with posterior segment involvement.. The diagnosis of BD will reached according to the criteria of the International Study Group for Behcet’s Disease. Subjects with at least 2 months of lesion-free period were regarded in the inactive disease period, and subjects with any oral, skin, and/or genital lesions will regarded as in the active disease period. Patients and healthy volunteers that were matched for age and gender included in this study
Exclusion criteria
Patients and healthy volunteers who were on any kind of medication including corticosteroid and immunosuppressive therapy, who had smoking (smoke more than 1 cigarette per day) and drinking ( >1 standard drink per week) habits, or who had history of systemic and ocular disease will not included in the study
Outcome results
None listed