None listed
Conditions
Brief summary
This study aims to identify the prevalence of hypoglycaemia during extended OGTTs and associations with biochemical parameters relevant to glucose metabolism. In particular, this study will explore the role of glucagon and the incretins GLP-1 and GIP in reactive hypoglycaemia during OGTTs.
Interventions
Participants will undergo an extended oral glucose tolerance test (OGTT) at their annual scheduled OGTT. This study will measure insulin and glucose at 30 minutes and 3 hours in addition to routine fasting, 1-hour and 2-hour measurements. Blood samples will also be collected at each of the 5 timepoints to measure additional hormones including glucagon, glucagon-like peptide-1 (GLP-1) and gastric inhibitory protein (GIP).
Sponsors
Academic Department of Adolescent Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
Group 1: Patients at the RPA CF clinic who have experienced hypoglycaemia on a previous OGTT Group 2: Patients at the RPA CF clinic who have reported symptoms suggestive of hypoglycaemia to a clinic health professional Group 3: Pre-transplant, non-liver disease patients at the RPA CF clinic who have normal glucose tolerance in the absence of previous hypoglycaemia on OGTT and previously reported hypoglycaemia.
Exclusion criteria
Women who are pregnant or lactating Patients who have had a lung transplant Patients who are identified to have cystic fibrosis related diabetes (CFRD), insulin and oral hypoglycaemic medications People with significant cognitive impairment, mental illness, or involved in an illegal activity who are unfit for participation
Outcome results
None listed