None listed
Conditions
Brief summary
The proposed project aims to investigate: 1) if aerobic exercise in the form of treadmill walking acutely relieves pain through exercise-induced analgesia (EIA); 2) if any EIA varies with the dose of exercise; and 3) the relationships between measures of pain and EIA with physical activity levels, sleep and mood in people with PD. We hypothesize that people with Parkinson's disease will have the usual exercise-induced analgesia response to exercise, and that this response will be stronger with a higher dose of exercise. We hypothesize that increased physical activity, better sleep and better mood will be associated with a better exercise-induced analgesia response and with less pain in people with Parkinson's disease.
Interventions
All participants will be asked to perform 2 separate bouts of aerobic treadmill walking exercise, around 1 to 2 weeks apart, in order to assess exercise induced analgesia/hyperalgesia. The exercise will be supervised by an accredited exercise physiologist or a registered physiotherapist. The duration of the exercise will be 10 to 25 min, depending on the fitness and walking capacity of the participant. The two sessions of treadmill walking will be performed at different intensities, one at low
All participants will be asked to perform 2 separate bouts of aerobic treadmill walking exercise, around 1 to 2 weeks apart, in order to assess exercise induced analgesia/hyperalgesia. The exercise will be supervised by an accredited exercise physiologist or a registered physiotherapist. The duration of the exercise will be 10 to 25 min, depending on the fitness and walking capacity of the participant. The two sessions of treadmill walking will be performed at different intensities, one at low intensity (Rating of Perceived exertion (RPE) 9-10 out of 20 – light exercise) and one at a higher intensity (RPE 12-13 out of 20 – moderate exercise). The order of the walking intensity will be randomised using a computer-generated table. Participants with PD will be asked to wear an activity and sleep monitoring device on their wrist and their waist for 7 consecutive days between the two treadmill walking sessions.
Sponsors
The University of Sydney
Study design
Allocation
Non-randomised trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
People with PD: Aged 40 years or over, living in the community and are able to walk at least 200m with or without a walking aid. No changes to their usual Parkinson's disease medications in the prior 2 weeks. Healthy Control Group Aged 40 years or over, living in the community
Exclusion criteria
People with PD: People with neurological impairments other than those due to Parkinson's disease. People with substantial cognitive impairment (i.e. mini-mental state examination below 24) People with pain due to a known radiculopathy (i.e. a compressed nerve of the spine) or another diagnosed chronic pain condition (e.g. fibromyalgia) that is likely to interfere with the evaluation of the person’s safety and of the study outcome. People with uncontrolled cardiovascular, metabolic or renal disease. Healthy control group People with neurological impairments. People with substantial cognitive impairment (i.e. mini-mental state examination below 24) People who experience significant pain (i.e. pain of >3/10 intensity for at least 2 days per week in the prior 3 months) People with pain due to a known radiculopathy (i.e. a compressed nerve of the spine) or another diagnosed chronic pain condition (e.g. fibromyalgia) that is likely to interfere with the evaluation of the person’s safety and of the study outcome. People with uncontrolled cardiovascular, metabolic or renal disease.
Outcome results
None listed