None listed
Conditions
Brief summary
Obesity is a major modifiable risk factor for cardiovascular disease, diabetes, and certain type of cancers. It poses a large global economic burden, costing billions of dollars annually for healthcare and productivity losses. The consumption of low energy dense foods has the potential to reduce total energy intake and aid in body weight management. In addition, recent studies suggest that taste qualities of a meal (e.g. savoury or sweet) may play a role in satiation and food intake. Therefore the objective of this randomised crossover study is to examine the effects of consuming preloads that differ in energy density (low or high) and taste quality (savoury or sweet) on postprandial glucose response and energy compensation among Asians. The proposed study will provide novel insights regarding the glycaemic and satiety responses to high energy-dense and low energy-dense foods and the role of taste quality in modifying these responses.
Interventions
This study will be conducted using a randomised crossover design with four treatments: low energy dense savoury preload (around 50 kcal with monosodium glutamate (MSG) and inosine 5’-monophosphate (IMP)), low energy dense sweet preload (around 50 kcal with sucralose), high energy dense savoury preload (around 250 kcal with MSG and IMP), and high energy dense sweet preload (around 250 kcal with sucralose).
All potential participants will be asked to attend a screening session after a 10-hour ov
This study will be conducted using a randomised crossover design with four treatments: low energy dense savoury preload (around 50 kcal with monosodium glutamate (MSG) and inosine 5’-monophosphate (IMP)), low energy dense sweet preload (around 50 kcal with sucralose), high energy dense savoury preload (around 250 kcal with MSG and IMP), and high energy dense sweet preload (around 250 kcal with sucralose). All potential participants will be asked to attend a screening session after a 10-hour overnight fast for consenting and screening procedures. Some basic anthropometric measurements such as height, weight, waist and hip circumferences will be taken. Body composition will be measured using Tanita BC-418 machine and BODPOD. Blood pressure will be taken using an automated blood pressure monitor. After the screening visit, participants will be asked to attend four test sessions, with a minimum of five-day washout period between the test sessions. On each test day, participants will be asked to consume a pre-package study breakfast outside Clinical Nutrition Research Centre (CNRC) between 8 am and 9 am. The study breakfast consists of a packet of Milo, an apple, a packet of biscuit, and a muesli bar. Participants will be asked to arrive at CNRC three hours after breakfast (between 11 am and 12 pm), where they will be provided with a study preload which must be consumed within a 15-minute time period. The preload is made up of soup with ingredients such as yam, sweet potato, corn, and snow fungus. Participants will be provided with an ad libitum lunch an hour after the commencement of preload consumption, where they are allowed to consume as much or as little as they wish until they feel comfortably full. Food consumption will be supervised by research staff. Fingerprick blood samples will be obtained at baseline (prior to preload consumption), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, and 180 minutes after commencement of preload consumption. Participants will be asked to complete an appetite-rating questionnaire at the same time points. All participants will be asked to complete a physical activity questionnaire and one-day diet record a day before their test day and the actual test day.
Sponsors
Singapore Institute for Clinical Sciences, A*STAR
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
Male
Age
21 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
The inclusion criteria for this study are healthy males aged between 21 and 50 years with normal BMI (18.5 to 25.0 kg/m2).
Exclusion criteria
The exclusion criteria are as follows, (a) People with major chronic disease such as heart disease, cancer or diabetes mellitus (b) Individuals whose body weight has changed more than 5 kilograms in the last 12 months (c) People who are taking insulin or medications known to affect glucose metabolism, appetite or energy metabolism (d) Individuals who are currently dieting (e) People with intolerance or allergy to study foods
Outcome results
None listed