Characterization of selenium and glutathione status in critically ill children.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12616001119482

Enrollment

160

Registered

2016-08-17

Start date

2014-04-04

Completion date

2015-04-08

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Reduced serum selenium concentration is common in adult critically ill patients and correlates to increased morbidity and mortality. Parallel supplementation has in a few studies shown reduced mortality rate and less infectious complications. Pediatric critically ill have not been studied and normal values for Scandinavian pediatric population is not known. Selenium supplementation in premature neonatal have shown less infectious complications. In this study we aim to characterize the normal serum concentration of selenium in healthy children to be commenced for elective surgery (n=60). In parallel pediatric critically ill including newborns (n=100) will be characterized concerning selenium- and glutathione status. This approach might reveal anti-oxidative capacity and mechanisms. Secondary aims are to investigate if the selenium- and glutathione profiles correlate to length of stay and severity of illness (PELOD, PIM2).

Interventions

Serum selenium concentration and glutathione status will be measured at admission and at day 5 in critically ill children and newborns.

Eligibility

Sex/Gender

All

Age

No minimum to 18 Years

Healthy volunteers

Yes

Inclusion criteria

<18 years of age; BW >1000 grams; expected time in PICU >24 hours

Exclusion criteria

BW <1000 grams; Age >= 18 years; Expected time in PICU <24 hours; moribund patient

Outcome results