Cognitive and Psychosocial Assessment After Mechanical Ventilation in Intensive Care - Does an Experience of Delirium Make a Difference?

Cognitive and Psychosocial Assessment After Mechanical Ventilation in Intensive Care - Does an Experience of Delirium Make a Difference: exploring cognitive and psychosocial outcomes following mechanical ventilation of patients in Intensive Care Unit (ICU) - one year follow up after ICU discharge.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12616001116415

Acronym

CAPA

Enrollment

162

Registered

2016-08-17

Start date

2012-10-08

Completion date

2016-09-30

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We aim to evaluate the hypothesis that an experience of delirium during mechanical ventilation in the ICU impacts negatively on patients’ cognitive and psychosocial outcomes. This is an observational, prospective study that is conducted in two Intensive Care Units in Australia: The Canberra Hospital in the Australian Capital Territory; and the Prince of Wales Hospital in Sydney, New South Wales. The study aims to recruit 162 patients who have been mechanically ventilated for more than 24 hours, and who meet the study’s inclusion/exclusion criteria. Outcome assessments will be recorded at ICU discharge, and at six and 12 months after ICU discharge. We aim to evaluate the hypothesis that an experience of delirium during mechanical ventilation in the ICU impacts negatively on patients’ cognitive and psychosocial outcomes.

Interventions

We are following patients who were mechanically ventilated for more than 24 hours in the Intensive Care Unit. We check for the presence of Delirium during their ICU admission by administering the Confusion Assessment Method for the ICU (CAM-ICU). CAM-ICU is a validated and widely used instrument for diagnosing delirium with yes/no questions administered to non-speaking, mechanically ventilated ICU patients. Based on this assessment, we allocate patients into the delirium positive and the delirium negative group. Positive delirium is diagnosed if patients have following present: 1) Acute onset and fluctuating course of Mental State; 2) Inattention; and either 3) Altered Consciousness, or 4) Disorganised Thinking. Both delirium positive and delirium negative groups are then followed up for 12 months. .

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Mechanical ventilation for more than 24 hours 2. Older than 18 years of age.

Exclusion criteria

1. Suspected acute primary brain lesion 2. End stage liver failure or acute hepatic failure 3. CALD background 4. Death is deemed imminent and inevitable 5. Patient is a Nursing Home Resident 6. Apache II Score of underlying terminal illness.

Outcome results