None listed
Conditions
Brief summary
This study aims to examinie the acute administration effects of curcumin, on a cohort already taking long-term curcumin. In an earlier study within another investigator team a report of a significant effect was observed one hour after administration of curcumin within sustained attention and working memory tasks of the intervention group as compared to placebo group. Given that the KARVIAH study design provides an opportunity to re-test this hypothesis, using a different formulation of curcumin, we would like to undertake the following as a sub-study with those participants who have completed their final assessment time-point within the curcumin study.
Interventions
This is a sub-study of an existing trial examining the influence of long term administration of curcumin (500mg 3 times daily) in an older population (ACTRN 12613000681752).
Participants within the existing curcumin study will be eligible to participate in this sub-study investigating the acute influence of curcumin, on those already consuming a chronic dose.
In the early morning, prior to taking their prescribed investigational product (IP) curcumin, the participants will undertake cognitiv
This is a sub-study of an existing trial examining the influence of long term administration of curcumin (500mg 3 times daily) in an older population (ACTRN 12613000681752). Participants within the existing curcumin study will be eligible to participate in this sub-study investigating the acute influence of curcumin, on those already consuming a chronic dose. In the early morning, prior to taking their prescribed investigational product (IP) curcumin, the participants will undertake cognitive testing using a computerised battery and complete a questionnaire to evaluate their working memory, attention and mood. They will then be provided a standardised breakfast and administered their usual investigational product, (oral Curcumin 500mg or placebo), as previously randomised in the main ACTRN 12613000681752 study. Exactly 1 hour post the investigational product participants will repeat the cognitive battery to examine the influence of curcumin or placebo on working memory, attention and mood. A standardised morning tea will then be provided at a designated time. Exactly 3 hours post the IP dose the participants will repeat the cognitive battery and questionnaire to examine the influence of curcumin or placebo on working memory, attention and mood as compared with baseline.
Sponsors
Macquarie University
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
Participant within the KARVIAH study - ACTRN 12613000681752 Cognitively healthy participants, as determined by the MoCA score. Able to undertake a computerised battery No evidence of depression Male or female (full inclusion as per main study)
Exclusion criteria
Diagnosis of dementia based on the revised criteria from NIA / AA or evidence of cognitive decline suggesting MCI Evidence of depression based on the DASS (full exclusion as per main study)
Outcome results
None listed