None listed
Conditions
Brief summary
There has never been a more sedentary population than the 21st century western society, with physical inactivity accounting for a similar number of deaths per annum as tobacco. Physical inactivity is a modifiable risk factor for chronic disease, especially cardiovascular diseases, and no other intervention possesses the broad spectrum of health impacts that can be attributed to exercise. However, the cardiovascular response of an individual to exercise is idiosyncratic and, whilst most individuals incur favourable effects, a sizeable proportion (~30%) of individuals either do not respond or respond “adversely” to exercise. The current research study aims to answer two fundamental questions. Firstly, is non-response to one exercise modality universal across all modalities? Secondly, to what extent is non-response to exercise environmentally versus genetically determined?
Interventions
Twin pairs will be randomised to simultaneously undertake 36 sessions of 3 sessions per week of either resistance or endurance training. This will be followed by a 12 week washout period. Each twin pair will then cross-over to start a similar period of training with the alternate intervention.
Each exercise session will last for 1 hr and be group, centre-based and supervised by and exercise scientist at the UWA Sport Science research gym. Adherance will be monitored by registering attendance at
Twin pairs will be randomised to simultaneously undertake 36 sessions of 3 sessions per week of either resistance or endurance training. This will be followed by a 12 week washout period. Each twin pair will then cross-over to start a similar period of training with the alternate intervention. Each exercise session will last for 1 hr and be group, centre-based and supervised by and exercise scientist at the UWA Sport Science research gym. Adherance will be monitored by registering attendance at each session. The resistance training will consist of weighted exercises at an intensity according to RPE (>14/20) and endurance training will consist of running and cycle ergometer at intensity according to HR max (60%+).
Sponsors
Winthrop Professor Daniel Green
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
15 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy twin pairs aged 15-40yrs will be recruited. We will recruit twin pairs via advertisement in the Perth metropolitan area via flyers. Additionally, we have approval from the Australian Twin Registry (ATR) to use their database.
Exclusion criteria
>4 units alcohol/day, medical conditions that compromise survival (i.e. cancer) or render subjects unable to exercise, BMI>35, history of myocardial infarction, coronary artery disease, stroke, chronic heart failure, diabetes. Cardiovascular medications or supplements that affect cardiovascular function will also constitute exclusions. Twins completing >150mins/wk of exercise will be excluded.
Outcome results
None listed