Is there a relationship between mannose binding protein deficiency and infections in people with autoimmune inflammatory conditions?

Frequent UrInary Tract Sepsis in Auto-Immune, Lupus-like And other immune-inflammatory Diseases: Is there a correlation with mannose binding lectin deficiency?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12616001076460

Acronym

FRUIT SALAD project

Enrollment

341

Registered

2016-08-10

Start date

2016-06-30

Completion date

2016-08-30

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Project Aim: To determine whether there is a relationship between low Mannose Binding Lectin concentrations (a protein produced in the liver, that acts in the recognition of disease causing pathogens) and frequent Urinary Tract Infections (UTIs) in patients who have an autoimmune disease. Hypothesis: MBL deficiency predisposes to frequent UTIs in female patients with auto-immune diseases

Interventions

341 people (from a private practice clinic) with diagnosed autoimmune inflammatory disease that have had mannose binding lectin levels recorded will be posted a questionnaire to determine the number and frequency of infection over the past 7 years. Those who fail to return the questionnaire will receive a follow up phone call 4 weeks later.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Physician diagnosed auto-immune disease such as: Rheumatoid Arthritis Systemic Lupus Erythematous Psoriatic arthritis Ankylosing Spondylitis Pre-determined MBL concentrations (determined for other reasons)

Exclusion criteria

Males Patients without diagnosed auto-immune disease Patients without MBL concentrations

Outcome results