None listed
Conditions
Brief summary
The prevalence of obesity is epidemic in Australia, and current public health, surgical and pharmaceutical strategies have had limited success in alleviating this health crisis. While numerous options are currently available for treatment of complications associated with obesity, most do not result in sustained weight reduction. Fundamentally obesity results from an imbalance between energy intake and expenditure, therefore the search for new methods that correct this imbalance are essential for effective long-term treatment. Rodent studies demonstrate that some types of fat tissue can burn a significant amount of energy, therefore targeting fat tissue via increasing its energy expenditure in humans is potentially a powerful tool for the treatment of obesity related disorders. Therefore understanding energy expenditure in upper thoracic fat in response to increased energy intake will impact possible future treatments aimed at manipulating energy expenditure in this tissue. Aim: to determine whether energy expenditure in upper thoracic fat tissue is altered by overeating. Hypothesis: over-eating will increase energy expenditure in upper thoracic fat tissue.
Interventions
The treatment diet is a 1 wk diet Intervention in lean and obese individuals. This diet will contain double the energy content of the control weight maintenance diet. All food will be given to participants by the researchers, which they will take home to eat unsupervised. The composition of this diet will be made up of whole foods identical to the control diet, with the additional energy to be provided primarily by high energy liquid meal replacements such as Sustagen, protein supplement beverag
The treatment diet is a 1 wk diet Intervention in lean and obese individuals. This diet will contain double the energy content of the control weight maintenance diet. All food will be given to participants by the researchers, which they will take home to eat unsupervised. The composition of this diet will be made up of whole foods identical to the control diet, with the additional energy to be provided primarily by high energy liquid meal replacements such as Sustagen, protein supplement beverages and flavoured milk. Participants will be free to eat and drink allocated for for a given day at any time they please, They will simply be asked to ensure they eat all of the food provided to them. All food will be provided to participants to be consumed in place of their regular diets. Food diaries will be provided to participants and they will be asked to record all food eaten including any additional food/drinks they consume. Water can be consumed ad libitum. Washout between control and treatment diets will be three weeks.
Sponsors
Baker IDI Heart and Diabetes Institute
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
Male
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
Males aged 18 – 35 years Unmedicated No major illness Lean group: BMI less than 25 kg/m2 Obese group: BMI 30-40 kg/m2
Exclusion criteria
Unable to give informed consent females Smokers Regular continuous exercise of >2 hours and/or 4 days per week of moderate or greater intensity. Claustrophobia Vegetarians/vegans Those with lactose intolerance Individuals who have been exposed to radiation in the last 5 years for research purposes (excluding DEXA scanning) Individuals with food allergies such as nut or dairy allergies
Outcome results
None listed