None listed
Conditions
Brief summary
During continuous renal replacement therapy (CRRT), blood is passed through a multi-lumen extracorporeal circuit that includes access, filter, return, effluent and replacement/dialysate components. Although anticoagulants, such as heparin and citrate, are commonly used, clotting of extracorporeal circuit and filter commonly occurs leading to shortened therapy duration or a failure to delivery therapy. In addition, inadequate treatment leads to circuit loss (including increased blood loss), increased costs (of circuits) and a loss of nursing time. The relationship between circuit pressures and artificial kidney failure in CRRT remains unclear. In response, we wish to perform an analysis of CRRT filter and circuit pressures in order to determine the patterns of change associated with artificial kidney failure. Specifically, we wish to evaluate the relative contribution of access circuit, filter, effluent, return circuit and trans-membrane (across the filter) pressures on the lifespan of the artificial kidney. In this pilot investigation we feel that 100 CRRT circuits will provide sufficient quantity of data to aid in the description of patterns of circuit pressure changes occurring during CRRT. Significantly, the findings of this study would provide insight into the dynamic changes of circuit pressures during CRRT, and defined the patterns of artificial kidney failure in CRRT. Such information will inform future prospective investigations aimed at improving the care of critically ill patients requiring CRRT. We plan to publish the audit findings in peer-reviewed critical care or artificial kidney injury journals. Participant anonymity and confidentiality will be preserved as only aggregated findings will be presented or reported.
Interventions
To perform an analysis of continuous renal replacement therapy filter and circuit pressures that are monitored and recorded throughout the entire dialysis treatment period in order to determine the patterns of change associated with artificial kidney failure. Patient's will be followed through their intensive care unit admission in order to obtain continuous renal replacement therapy utilization through to hospital discharge.
Sponsors
Austin Health
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adult critically ill patients who are receiving continuous renal replacement therapy as determined by their treating intensive care unit physician.
Exclusion criteria
Those aged less than 18 years, not admited to an intensive care unit and who do not receive renal replacement therapy as a part of their care during their admission to the intensive care unit.
Outcome results
None listed