None listed
Conditions
Brief summary
A pilot study of the metabolic effects of long term consumption of SunGold kiwifruit in healthy subjects. The primary hypothesis is that two kiwifruit consumed daily for six weeks will not have any harmful effect as measured by risk factors for cardiovascular disease. The purpose of the study is to establish whether or not the increased intake of fructose and glucose resulting from daily ingestion of two kiwifruit could lead to harmful metabolic change, or exposure to glycaemia. Conversely, whether the increase in Vitamin C and other phytochemicals as a result of consuming kiwifruit could protect against the processes of inflammation and oxidation that lead to long term damage will also be investigated by measuring changes in several biomarkers indicative of inflammation and oxidation in the kiwifruit versus non-kiwifruit groups. The study will employ a randomised cross-over design in which all subjects ingest two kiwifruit per day or no kiwifruit (their normal diet minus kiwifruit) for six weeks. There will be a kiwifruit-free lead in period of three weeks, a three week washout at cross over, and a kiwifruit-free follow up of three weeks. Blood samples will be taken five times from all subjects: at the end of lead in, after intervention 1, after washout, at the end of intervention 2, and at the end of the follow up.
Interventions
The intervention is six weeks of consuming two 'SunGold' kiwifruit per day as part of the customary diet, with the exclusion of vitamin supplements. The control treatment is the customary diet with the exclusion of kiwifruit and vitamin supplements. For all participants there is a three week kiwifruit-free lead in period, a three week kiwifruit-free wash out period at cross-over, and a three week kiwifruit free follow up at the end of the second intervention.
Kiwifruit consumption will be monit
The intervention is six weeks of consuming two 'SunGold' kiwifruit per day as part of the customary diet, with the exclusion of vitamin supplements. The control treatment is the customary diet with the exclusion of kiwifruit and vitamin supplements. For all participants there is a three week kiwifruit-free lead in period, a three week kiwifruit-free wash out period at cross-over, and a three week kiwifruit free follow up at the end of the second intervention. Kiwifruit consumption will be monitored and recorded during weekly delivery of kiwifruit.,to subjects
Sponsors
New Zealand Institute for Plant & Food Research Limited
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
Male
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Good health. No intolerance of kiwifruit. BMI 20-35 kg/m2 Age 20-60 years. Willingness to comply with demands of the trial.
Exclusion criteria
Intolerance of kiwifruit. Ill health Glucose intolerance.
Outcome results
None listed