None listed
Conditions
Brief summary
We will use a test of a balance (Vestibular Evoked Myogenic Potential) in people with vestibular migraine and those without. This study aims to see whether the test could help to diagnose vestibular migraine. If useful, it may assist in the diagnosis of vestibular migraine. Previous studies have suggested that the test produces abnormal results. We will be excluding the primary differential diagnosis of vesibular migraine (Meniere's disease) from our vestibular migraine group using electrocochleography, an objective test for Meniere's disease. It is hypothesised that the vestibular test results will be the same between healthy controls and patients with vestibular migraine.
Interventions
Both cervical VEMPs and ocular VEMPs will be measured in all participants at a Public Hospital by Jon Osborne, an Masters of Audiology student. Following placement of skin electrodes on the neck and below the eyes, the vestibular system will be stimulated using high level (starting at 100 dB HL before reducing intensity to determine threshold) 500 and 1000 Hz tone bursts via TDH headphones to each ear.
The rise and fall time of the tone burst will be set to 1 ms with a 2 ms plateau. The tone b
Both cervical VEMPs and ocular VEMPs will be measured in all participants at a Public Hospital by Jon Osborne, an Masters of Audiology student. Following placement of skin electrodes on the neck and below the eyes, the vestibular system will be stimulated using high level (starting at 100 dB HL before reducing intensity to determine threshold) 500 and 1000 Hz tone bursts via TDH headphones to each ear. The rise and fall time of the tone burst will be set to 1 ms with a 2 ms plateau. The tone bursts will be presented at 10 Hz, and 256 repetitions will be used to produce a waveform (Lasting about 26 seconds). Electromyography activity will be recorded using a CED 1902 bioamplifier and National Instruments USB6215 DAQ attached to a laptop. There are no known risks associated with VEMPs. However the sound levels may be uncomfortable. All testing will be performed on one day, and will take less than an hour. The cVEMPs and oVEMPs are not being compared directly.
Sponsors
Dr Rebecca KellyCampbell
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
For Vestibular Migraine group: A. At least five episodes fulfilling criteria C and D B. A current or past history of Migraine without aura or Migraine with aura C. Vestibular symptoms of moderate or severe intensity, 3 lasting between 5 minutes and 72 hours D. At least 50% of episodes are associated with at least one of the following three migrainous features: 1. headache with at least two of the following four characteristics: a) unilateral location b) pulsating quality c) moderate or severe intensity d) aggravation by routine physical activity 2. photophobia and phonophobia 3. visual aura E. Not better accounted for by another ICHD-3 diagnosis or by another vestibular disorder. The only criteria for the healthy controls are the exclusion criteria.
Exclusion criteria
For Vestibular Migraine 1. conductive hearing loss, determined by either pure tone audiometry or tympanometry. 2. inability to maintain tonic EMG neck activity by raising their head from a supine position 3. inability to maintain eye gaze in the superomedial direction. For Healthy Controls: Exclusion criteria for healthy controls: 1. significant history of balance/vertigo problems, or headache/migraine. 2. conductive hearing loss, determined by either pure tone audiometry or tympanometry. 3. inability to maintain tonic EMG neck activity by raising their head from a supine position 4. inability to maintain eye gaze in the superomedial direction.
Outcome results
None listed