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Fluid status after bowel preparation for colonoscopy: objective assessment and relationship to hypotension under sedation

Fluid status after bowel preparation for colonoscopy: objective assessment and relationship to hypotension under sedation

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12616000614493
Enrollment
104
Registered
2016-05-11
Start date
2017-04-26
Completion date
2019-03-28
Last updated
2023-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study is important in defining the baseline physiological state of patients presenting for outpatient endoscopy. It has been observed that intravenous fluids do not prevent hypotension in patients who are undergoing endoscopy. One possible explanation for this is that patients are not intravascularly deplete after bowel preparation solution. This study will determine what the rate of intravascular depletion in patients undergoing endoscopy after bowel preparation solution is.

Interventions

In patients who have taken bowel preparation solution for an endoscopy examination (colonoscopy +/- gastroscopy) their intravascular fluid status will be assessed using echocardiography views before and after passive leg raise testing. The volume assessment will take approximately 20minutes and occur immediately prior to the endoscopy procedure start. This aims to determine if patients are intravascularly deplete prior to endoscopy examination. All assessments will be completed on the day of

In patients who have taken bowel preparation solution for an endoscopy examination (colonoscopy +/- gastroscopy) their intravascular fluid status will be assessed using echocardiography views before and after passive leg raise testing. The volume assessment will take approximately 20minutes and occur immediately prior to the endoscopy procedure start. This aims to determine if patients are intravascularly deplete prior to endoscopy examination. All assessments will be completed on the day of the procedure.

Sponsors

Megan Allen
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. Electively booked endoscopy procedure 2. Adult patients undergoing endoscopy procedures where bowel preparation solution has been administered (colonoscopy, gastroscopy combined with colonoscopy with both diagnostic and therapeutic intent including polypectomy) 3. Language and cognitive ability to understand and comply with study requirements 4. No local injury or contraindication to the use of transthoracic echocardiography (TTE) imaging

Exclusion criteria

1. Emergency procedures 2. Patients undergoing endoscopy without receiving, or not completing, bowel preparation solution 3. Patients with language or cognitive barriers to full understanding of the study procedures and the ability to obtain consent 4. Patients undergoing advanced endoscopic procedures (ERCP, enteroscopy, endoscopy via stoma, banding haemorrhoidectomy) 5. Contraindication to the use of transthoracic echocardiography

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026