The efficacy of intravenous ibuprofen and pregabalin before posterior lumbar stabilisation surgery on postoperative pain.

Comparison of pregabalin and pregabalin+ intravenous ibuprofen for preemptive (before the procedure) analgesia for posterior lumbar stabilisation operation.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12616000591459

Enrollment

Registered

2016-05-06

Start date

2016-06-01

Completion date

2016-09-20

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

For managing acute postoperative pain, new medical treatments administered preoperatively. For this purpose, pregabalin has been used previously for lumbar fusion surgery in some clinical research. Intravenous ibuprofen ( NSAID analgesic) used until 2009. We want to investigate the effect of pregabalin+intravenous ibuprofen used before the operation preemptively on postoperative analgesia for lumbar fusion surgery. We enroll 42 patients who undergone elective lumbar fusion surgery. Exclusion criteria; antiepileptic drug use, allergic reaction for study drugs, ASA III-IV patients. mild or severe renal insufficiency. Group Pregabalin: 1 hour before operation patients will take 150 mg pregabalin oral form. Group Pregabalin + intravenous ibuprofen: 1 hour before operation patients will take 150 mg pregabalin oral form. Additionally 1/2 hour before operation patients will take 800 mg intravenous ibuprofen. After operation we give patient controlled analgesia contains morphine, and we will evaluate postoperative pain.

Interventions

For postoperative pain we will give one group of patients ( 21 patients for each group) pregabalin 150 mg oral form 1 hour before the operation. The other group will take pregabalin like group 1 and intravenous ibuprofen 800 mg, 1/2 hour before the operation.

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

ASA ( american society of anesthesiologists) Physical Status 1-2, planned for elective posterior lumbar stabilisation surgery

Exclusion criteria

Antiepileptic drug use, ASA 3 patient groups, Mild or severe renal insufficiency.

Outcome results