None listed
Conditions
Brief summary
We hypothesise that people with anorexia requiring hospital admission for treatment will have abnormalities in appetite peptides, and that these may not return to normal even with weight restoration. A secondary hypothesis is that we may be able to identify a predictor of good outcome at 1 year. This study will collect serial blood samples in people admitted to Westmead Hospital for treatment of anorexia nervosa. Blood will be collected prior to refeeding and at the visits closest to 2, 4, 8, 16 weeks, 6 and 12 months.
Interventions
Nil interventions - all subjects will have routine clinical care.
Mostly they are inpatients for the first 4 weeks and will have baseline, 1, 2 and 4 week bloods collected to measure appetite peptides. Then they attend outpatients at roughly monthly intervals until stable. We will collect blood samples to measure appetite peptides at the outpatient visits most closely approximating 8, 16 and 26 weeks and 12 months..
We will observe weight regain and maintenance over the study period. Weight wil
Nil interventions - all subjects will have routine clinical care. Mostly they are inpatients for the first 4 weeks and will have baseline, 1, 2 and 4 week bloods collected to measure appetite peptides. Then they attend outpatients at roughly monthly intervals until stable. We will collect blood samples to measure appetite peptides at the outpatient visits most closely approximating 8, 16 and 26 weeks and 12 months.. We will observe weight regain and maintenance over the study period. Weight will be measured each visit with scales to the nearest 0.1kg, height will be assessed by stadiometer at first visit.
Sponsors
Dept of Endocrinology and Diabetes, Westmead Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 20 Years
Healthy volunteers
No
Inclusion criteria
New admission for treatment of anorexia nervosa. Age 14-20
Exclusion criteria
Age <14 or age >20. Not first admission for treatment of anorexia (i.e. second or subsequent presentation).
Outcome results
None listed