Remote ischaemic preconditioning and its effect on coronary physiology and platelet & leukocyte activation

Remote ischaemic preconditioning and its effect on coronary physiology and platelet & leukocyte activation in patients with suspected coronary artery disease undergoing coronary angiography.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12616000486426

Acronym

RIPPLE

Enrollment

153

Registered

2016-04-13

Start date

2014-10-17

Completion date

2019-08-26

Last updated

2022-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We are trying to establish the mechanism by which remote ischaemic preconditioning confers protection to the heart

Interventions

Patients will have remote ischaemic preconditioning delivered which involves inflating a sphygmomanometer to supra-systolic pressures around their arm. The sphygmomanometer will be inflated to 200mmHg or 50mmHg above systolic blood pressure for 5 minutes then deflated for 5 minutes. This cycle will be repeated 3 times. The treatment will be administered by a member of the research team. The participant will undergo the planned medical procedure after the remote ischaemic preconditioning.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients listed for coronary angiography +/- angioplasty and stenting

Exclusion criteria

Contraindications to remote ischaemic preconditioning- clinically unstable, peripheral vascular disease of upper limb, AVF in left arm, contraindications to adenosine, unable to co-operate/ consent, pre-existing neuropathy or myopathy

Outcome results