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Vascular adaptations to 8 weeks of different types of cycling in healthy older adults.

Vascular adaptations to 8 weeks of different types of cycling in healthy older adults.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12616000444482
Enrollment
57
Registered
2016-04-06
Start date
2016-04-18
Completion date
2016-10-17
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Exercise training is commonly used for the treatment and prevention of many chronic diseases. Of particular interest are the effects of exercise training to prevent many age-related changes, including reduction in blood vessel health and whole body fitness. Healthy older adults will be recruited to participate in an 8 week exercise training program where they will be randomised to one of three different cycle training groups: moderate intensity double-leg continuous cycling, high intensity double-leg interval cycling, or high intensity single-leg interval cycling. Measures of blood vessel function, heart structure and function, fitness and body composition will be obtained at baseline, 4 weeks (blood sample and vessel function only), 9 weeks and 16 weeks.

Interventions

Participants will be randomly assigned to one of three 8 week training interventions. All training sessions will be completed at the Murdoch University Exercise Physiology laboratories and will last approximately 40-75 minutes per session (depending on group allocation). Irrespective of the participant’s group allocation, all exercise sessions will be conducted with groups of up to six participants on a cycle ergometer (WattBike Pro or Trainer, Wattbike Australia, AUS). All exercise intensitie

Participants will be randomly assigned to one of three 8 week training interventions. All training sessions will be completed at the Murdoch University Exercise Physiology laboratories and will last approximately 40-75 minutes per session (depending on group allocation). Irrespective of the participant’s group allocation, all exercise sessions will be conducted with groups of up to six participants on a cycle ergometer (WattBike Pro or Trainer, Wattbike Australia, AUS). All exercise intensities will be prescribed according to a predetermined level of perceived exertion, using the Borg 6-20 rating of perceived exertion (RPE) scale, which is associated with a desired percent of aerobic capacity (VO2peak). Each session will begin and end with a 5 minute double-leg cycling based warm-up (intensity; RPE 11-13, 40-60% VO2peak) and cool down (intensity; RPE 8-10, 20-40% VO2peak). The moderate intensity double-leg continuous group will cycle continuously for 40 minutes at an RPE 11-13 (40-60% VO2peak) using normal double-leg cycling. The high intensity double-leg interval cycling group will complete twenty 30 second double-leg efforts at an RPE 15-17 (60-85% VO2peak) with each effort separated by 60 seconds of passive rest (RPE 6; <20% VO2peak). The high intensity single-leg interval cycling group will complete twenty 30 second single-leg efforts at an RPE of 15-17 with each effort separated by 60 seconds of passive rest (RPE 6). At the completion of the first twenty efforts, a short break will be provided (~5 minutes) prior to the participants completing another twenty efforts with the opposite leg. 3 sessions per week will be prescribed and monitored by Miss Nicole Gordon, an ESSA Accredited Exercise Physiologist. Program adherence will be monitored through exercise logs.

Sponsors

Murdoch University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Educational / counselling / training
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
45 Years to 75 Years
Healthy volunteers
Yes

Inclusion criteria

1. Healthy older adults between 45 and 75 years old 2. Able to attend Murdoch University Exercise Physiology Laboratory or Curtin University Exercise Physiology Laboratory 3 times per week for 8 weeks for approximately 16 to 30 hours in total (depending on group allocation). 3. Able to attend Murdoch University Exercise Physiology Laboratory for testing sessions at baseline, 4 weeks, 9 weeks and 16 weeks after commencement of the intervention (approximately 7 hours in total).

Exclusion criteria

1. Previously diagnosed with a cardiovascular or metabolic disorder 2. Pregnancy 3. Individuals who smoke regularly or have quit in the last 6 months 4. Must answer “no” the first seven questions in the Exercise and Sports Science Australia pre-screening tool or have a medical clearance from their general practitioner 5. Currently participating in a structured exercise training program, defined as >90 minutes per week of planned exercise for the purpose of improving health and fitness and/or performance

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026