None listed
Conditions
Brief summary
This project aims to substantiate the effects of acute ingestion of high pinitol carob fibre on glycaemic control and subjective satiety and appetite responses. A secondary aim is to distinguish any additional clinically relevent effects of the pinitol compared to the fibre alone. We hypothesise that high pinitol carob fibre within a cereal-based test food will lower glycaemic and insulinaemic responses and increase satiety resulting in lower dietary intake.
Interventions
Pinitol has been shown to demonstrate insulin signalling and the stimulation of glucose transport in humans. Research shows that carob is very high in pinitol in comparison to other legume products. Therefore, carob is a much viable source.
Three test foods will be consumed by 20 (15 people minimum) participants in a double-blind crossover design containing a control and two test meals. The control biscuit will contain moderate fibre within a commercial cereal-based biscuit (control), test meal
Pinitol has been shown to demonstrate insulin signalling and the stimulation of glucose transport in humans. Research shows that carob is very high in pinitol in comparison to other legume products. Therefore, carob is a much viable source. Three test foods will be consumed by 20 (15 people minimum) participants in a double-blind crossover design containing a control and two test meals. The control biscuit will contain moderate fibre within a commercial cereal-based biscuit (control), test meal one will contain high pinitol carob fibre (HPCF) and test meal two will contain a low pinitol carob fibre (LPCF). CONTROL Energy: 915 KJ Carob ingredient: 0 g Pinitol: 0 mg Carbohydrate: 33.1 g Dietary fibre: 3.8 g TEST MEAL 1 (HPCF) Energy: Approx. 900 KJ Carob ingredient: 6 g Pinitol: 600 mg Carbohydrate: 33 g Dietary fibre: 6 g TEST MEAL 2 (LPCF) Energy: Approx. 900 KJ Carob ingredient: 6 g Pinitol: <100 mg Carbohydrate: 33 g Dietary fibre: 6 g Two nutrition and dietetics honours students will be deliver the intervention, while the blood samples will be taken by trained nurse staff. The supervisors of this intervention are both trained as dieticians. Values will be determined after testing final product. Participants are required to have fasted overnight (12-hours). All three test foods will be consumed on separate occasions, with at least a 72 hour washout period. Blood samples taken to measure the effects of a high pinitol carob fibre (HPCF) cereal-based biscuit on glycaemic and insulin responses on appetite within humans. Adherence will be measured by using a 24-hour recall to monitor dietary intake the day before testing was maintained. As there is 3 separate, acute, testing days, subjects will only be required to maintain habitual dietary patterns.
Sponsors
University of Wollongong
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Overall good health, between the age of 18-60 years and a body mass index between 20-30 kg/m^2 (healthy to overweight range).
Exclusion criteria
Subjects with major or chronic diseases, eating habits incompatible with the studies aims (food allergies and/or religious, cultural or environmental habits that don’t correspond with the study), literacy and/or inadequate English. Pregnant, breastfeeding or women with menstrual irregularities (based on hormonal appetite), smoking, the use of antioxidant supplementation within four-weeks of the study commencement date and the unwillingness to stop fibre supplements will also be excluded from the study.
Outcome results
None listed