Pharmacokinetic study of four orally formulated combinations of acetaminophen and ibuprofen in healthy volunteers under fed conditions

Each participant will be randomly allocated to receive a single dose of each of the following treatments in a four-way cross-over sequence: - Treatment A: oral suspension containing 1000 mg acetaminophen + 300 mg ibuprofen in 31.25 mL - Treatment B: powder sachet containing 1000 mg acetaminophen + 300 mg ibuprofen for oral solution - Treatment C: tablets providing total dose of 1000 mg acetaminophen + 300 mg ibuprofen - Treatment D: tablets providing total dose of 975 mg acetaminophen + 292.5 mg ibuprofen The administration of doses will be supervised on site. All treatments will be administered under fed conditions. Participants will be fasted for at least 10 hours overnight and receive a standardized breakfast served 30 minutes prior to study drug administration. This breakfast will supply around 967 kcal about 50% of which are fat calories. A standardized meal will be served approximately 5 hours after dosing and a snack will be provided approximately 9 hours after study drug administration. Water will be restricted for 1 hour pre-dose and 1 hour post-dose (with the exception of water administered as part of dosing). Administration - Oral Suspension formulation: 31.25 mL of the oral suspension will be dispensed for consumption. Any residue remaining after initial administration will be resuspended with 240 mL of water and consumed. - Powder Sachet formulation: contents of the sachet will be dissolved in 240 mL hot water and consumed once cold. - Tablet Formulations: will be administered with 240 mL of water. Dose-frequency is single doses of four different formulations separated by a washout period of 3 days. All participants will complete the four periods in cross-over fashion.