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Exploration of alkaline supplements in healthy adults

Exploration of net endogenous non-carbonic acid production measurement, modulation and estimation using the Australian food database following administration of alkaline supplements in healthy adults

Status
Completed
Phases
Phase 1
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12616000417482
Enrollment
16
Registered
2016-04-01
Start date
2015-05-01
Completion date
2015-08-01
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The normal foods people eat release both acid and alkali into the human body. This is called the dietary acid-alkali load. Powdered vegetable (greens) supplements are currently marketed as alkalising to the body and are used by the public for this reason. The extent these supplements influence the dietary acid-alkali load has received little scientific attention. As such, this research will evaluate their capacity to modulate the dietary acid-alkali load. In addition, it may be possible to monitor the dietary acid-alkali load by urine pH (that is, by urine dipsticks). As such this research also aims to explore urine pH before and following greens supplementation

Interventions

The study was a double blind, randomised, placebo controlled, cross-over trial with a four day wash out period between two phases. The wash out period was selected as large alkaline loads are known to be excreted within 1 – 2 days following their caseation. The intervention consisted of a powdered fruit and vegetable supplement. 15g of the supplement was consumed in water 3 times daily for 3 days. To ensure compliance, the participants were met daily and questioned on their intake. The supplem

The study was a double blind, randomised, placebo controlled, cross-over trial with a four day wash out period between two phases. The wash out period was selected as large alkaline loads are known to be excreted within 1 – 2 days following their caseation. The intervention consisted of a powdered fruit and vegetable supplement. 15g of the supplement was consumed in water 3 times daily for 3 days. To ensure compliance, the participants were met daily and questioned on their intake. The supplement was approved as safe by the University of the Sunshine Coast's Human Ethics committee (reference number: S/14/70). The supplement is also commercially available. The following is the ingredients list printed on the nutritional supplement: Certified Organic barley grass juice (5%)*, Certified Organic wheat grass juice (5%)*, Carrot, Apple fibre pectin, Lime, Pineapple, Apple, Kiwifruit, Prebiotic fibre (Fructooligosaccharides), Lemon, Calcium citrate, L-Glutamine, Natural fruit flavours, Green capsicum, Prebiotic fibre (Inulin), Broccoli sprouts, Certified Organic broken cell chlorella (2.5%)*, Magnesium citrate, Xylitol (natural sweetener derived from corn), Broccoli, Potassium bicarbonate, Guar gum, Brown seaweed extract (Fucoidan), Spinach, Bromelain, Daikon radish sprouts, Celery, Alfalfa sprouts, Parsley, Probiotic culture blend [1 million cfu/serve (Lactobacillus acidophilus, Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum)], Dandelion leaves extract, Withania extract, Certified Organic spirulina (0.5%)*, Asparagus, Cucumber, Kelp extract, Aloe vera extract, Siberian ginseng extract, Shitake mushroom extract, Maitake mushroom extract, Natural flavour masker, Stevia extract, Chlorophyll, Black pepper extract. *indicates certified organic by the Australian Certified Organic Standard

Sponsors

Dr Gary Slater
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver)

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

Participants were included if they were between 18–65 years old

Exclusion criteria

Participants were excluded if they used medication (except birth control), alkaline water or mineral and herbal supplements. Furthermore, those with a diagnosed health issue, BMI of <18 kg/m2, or pregnant were excluded.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026