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The LIFTMOR for Men trial: Is heavy resistance training or a machine-based isometric exercise program more effective at reducing risk of fracture in older men with reduced bone mass?

A randomised controlled trial to determine the effectiveness of heavy progressive resistance training versus high load machine-based isometric resistance training to reduce the risk of osteoporotic fracture in older men with low bone mass

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12616000344493
Acronym
LIFTMOR (for Men): Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation
Enrollment
93
Registered
2016-03-16
Start date
2016-05-01
Completion date
2018-07-30
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Recent work undertaken at Griffith University (the LIFTMOR trial) has revealed that brief exposure to a bone-targeted heavy progressive resistance training program is both safe, and effective for enhancing musculoskeletal health and function, in postmenopausal women with low to very low bone mass. Similar claims have been made by the developers of the bioDensity system, designed around the premise that low volume machine-based isometric resistance training produces beneficial effects on balance, physical function, muscle strength and bone mass. Whether dynamic or isometric resistance training will be more effective in middle-aged and older men with reduced bone mass at the hip and spine remains to be seen.

Interventions

The study is a three-arm, semi-randomised controlled exercise intervention trial. Eligible volunteers will be randomly allocated to one of two eight month, twice-weekly, 30-minute exercise programs; either supervised heavy progressive resistance training and impact loading, or machined-based isometric resistance training using the bioDensity system. Arm 1 – supervised heavy progressive resistance training and weight-bearing impact loading. Three compound movement exercises (deadlift, overhead

The study is a three-arm, semi-randomised controlled exercise intervention trial. Eligible volunteers will be randomly allocated to one of two eight month, twice-weekly, 30-minute exercise programs; either supervised heavy progressive resistance training and impact loading, or machined-based isometric resistance training using the bioDensity system. Arm 1 – supervised heavy progressive resistance training and weight-bearing impact loading. Three compound movement exercises (deadlift, overhead press, and squat) using olympic weights will be completed. For each exercise, 5 sets of 5 repetitions, corresponding to an intensity of 80-85 % of 1 repetition maximum will be performed. 5 sets of 5 repetitions of weight-bearing impact loading exercises (i.e. drop jumps) will also be performed, with height of the jump progressively increasing across the intervention period. Arm 2 – supervised high-load isometric exercise using the bioDensity system. A single set of four isometric exercises (chest press, leg press, core and arm pull, and vertical lift) will be performed according to bioDensity device specifications. For each exercise, one repetition of a self-initiated 75%-maximum contraction will be held for 5 seconds. Sessions are supervised by a single qualified trainer (Bachelor of Exercise Science with Honours, Level 1 Sports Trainer, Certificate III in Fitness), a PhD candidate in the School of Allied Health Sciences. Training diaries will be used to record participant attendance at exercise sessions, and the completion of each element of the training session. Compliance will be determined as the number of sessions attended as a percentage of total possible sessions.

Sponsors

Griffith University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)

Eligibility

Sex/Gender
Male
Age
45 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Men Apparently healthy With low bone mineral density (hip or spine BMD T-score less than or equal to -1.0) Not currently or recently participating in regular resistance training or impact-type exercise

Exclusion criteria

Current participation in resistance training or exercise with an impact-loading component Uncontrolled cardiovascular disease/respiratory conditions Neurological conditions which might limit an individual’s ability to perform resistance training Malignancy Hernia Medications know to adversely affect musculoskeletal health such as corticosteroids, anti-convulsants Medical conditions known to effect musculoskeletal health such as hyperparathyroidism, Paget’s disease, diabetes

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026