None listed
Conditions
Brief summary
40 healthy men age 70+ years old will be randomized to consume a weight maintenance diet containing either 0.8 or 1.6 g/kg/day of protein for 10 weeks. Muscle size, strength, lean body mass, physical function (SPPB and timed up and go), insulin sensitivity and gut microbiome composition will be measured before and after the 10 week dietary intervention period. Muscle fibre size will be measured via muscle biopsies taken before and after the intervention period.
Interventions
Participants will consume a controlled diet provided by the experimenters for 10 weeks. The diet will provide 1.6 g/kg/day of protein and will meet energy needs for each participant based on the Harris-Benedict equation. The diet will also consist of approximately 30% fat and 50% carbohydrate. Participants will be asked to record any food not consumed in a food diary.
Sponsors
University Of Auckland
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
Male
Age
70 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
*Healthy community dwellers (activities of daily living preformed unassisted) *BMI (18-35 kg/m2) *Sedentary to moderately active (structured activity of less than 4 hours per week) *No history of gastrointestinal disease or disturbance, or antibiotics use in the previous 3 months, or probiotic use in the preceding one month. Normal bowel frequency (minimum once every 2 days, maximum 3 times per day)
Exclusion criteria
*Receiving dietetic intervention or prescribed dietary supplements in the last month, including calcium and fish oil. *Receiving palliative care *History of alcohol abuse *Smoking *Participation in an investigational drug evaluation *On medications which may affect the muscle: however, ACE inhibitors, statins and calcium channel blockers will be allowed. *Advanced organic diseases: cardiac illness; myocardial infarction; thrombophlebitis; cerebrovascular disease *Major systemic disease diagnosed or active within the previous 20 years (e.g. cancer, rheumatoid arthritis) *Osteoarthritis, classified by inability to perform maximal contractions of upper and lower limbs without pain *Acute febrile illness within the previous 6 months *Metabolic disease (e.g. diabetes, obesity, thyroid disease) *Meat or dairy allergy, vegetarian
Outcome results
None listed