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Feasibility and potential benefits of high-intensity interval cycling for knee osteoarthritic patients: a randomised control feasibility trial?

Is high-intensity interval cycling feasible and more beneficial than continuous cycling for knee osteoarthritic patients: a randomised control feasibility trial?

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12616000273482
Enrollment
27
Registered
2016-03-01
Start date
2014-05-28
Completion date
2015-11-17
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Osteoarthritis (OA) is a degenerative joint disease affecting many middle-aged and older adults. As osteoarthritic symptoms typically involve joint pain and stiffness, individuals with OA of the knee are insufficiently physically active, have low levels of physical function and are at increased risk of other comorbidities, falls and reduced quality of life. While continuous moderate intensity cycling is often recommended for individuals with knee OA, little is known about the potential benefits and risks of high intensity interval training (HIIT) cycling for this population, even though this form of exercise is becoming more commonly utilised by a range of other chronic disease groups. This randomised controlled feasibility trial sought to gain some insight into the feasibility, safety and effectiveness of home-based HIIT compared to continuous cycling in middle-aged and older adults with knee OA. Methods: Middle-aged and older adults with knee OA were randomly allocated to either continuous (MICT) or HIIT home-based cycle training programs; with both programs requiring the performance of four cycling sessions (~25 minutes per session) each week. Participants were measured at baseline and post-intervention (8 weeks). Feasibility was assessed by withdrawal rate, adherence rate and number of adverse effects. Efficacy was assessed by the WOMAC, Lequesne index of severity for osteoarthritis of the knee, Timed Up-and-go (TUG) test; Sit-to-stand (STS), preferred gait speed and body composition.

Interventions

This randomised control trial study was conducted to gain some preliminary data on the feasibility and efficacy of high-intensity interva;l training (HIIT) vs moderate intensity continuous training (MICT) cycling for improving measures of body composition, physical function and disability in middle-aged and older knee OA patients. It was hypothesised that both forms of home-based exercise would be feasible and produce a range of functional and health benefits. The participants were requested to

This randomised control trial study was conducted to gain some preliminary data on the feasibility and efficacy of high-intensity interva;l training (HIIT) vs moderate intensity continuous training (MICT) cycling for improving measures of body composition, physical function and disability in middle-aged and older knee OA patients. It was hypothesised that both forms of home-based exercise would be feasible and produce a range of functional and health benefits. The participants were requested to perform four cycle sessions per week over the course of eight weeks, with each session lasting approximately 25 minutes. As a home-based intervention, there was no supervsion of the exercise sessions or quantitative assessment of exercise intensity performed by either group. The cycling program for the moderate intensity continuous training (MICT) group commenced with a 3 minute warm-up at a light intensity, followed by 20 minutes at a moderate intensity in which the participant was encouraged to cycle between 60-80 rpm at an appropriate workload and then to finish the training session with a 2 minute cool-down at a light intensity. Moderate intensity was defined as being “able to speak in complete sentences during the exercise. If you find yourself getting too ”puffed” or out of breath - slow down a little”. For those in the high-intensity interval training (HIIT) group, their training sessions commenced with a 7 minute warm-up of gradually increasing intensity and concluded with a 6 to 7 minute cool-down of light to moderate cycling. The HIIT component of the training session involved five series, with each series commencing with 45 s at a moderately high to high intensity followed by 90 s at moderately low intensity. For the 45 second high-intensity bouts, the participants were requested to cycle at a higher cadence (70-90 rpm) and resistance than they used in the 90 s recovery bouts, with the intensity of the high-intensity bouts being described as “an intensity at which you felt it was quite difficult to complete sentences during the exercise”. To monitor adherence, participants completed a training diary in which they stated the dates they performed exercise each week; with the explicit aim provided to the participants being to perform four sessions per week over the course of the eight week trial.

Sponsors

Bond University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

A confirmed diagnosis of knee osteoarthritis by an orthopaedic surgeon; were provided clearance by their physician to participate in the study and who were unlikely to change their osteoarthritic management during the course of the study were eligible to participate.

Exclusion criteria

Any other chronic diseases that pose contraindications for performing a home-based home exercise program e.g. unstable cardiac conditions; not having access to a stationary bicycle to perform the home-based program.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026