None listed
Conditions
Brief summary
Forty patients aged 65 and older planned for elective abdominal surgery were randomly divided into two groups. While 5 ml- physiological serum was administered to the control group, ketamine group received 0,5 mg/kg ketamine in IV form 5 minutes before induction. Hemodynamic variables,were measured every 15 min until the end of the operation. Standardized Mini Mental Test (SMMT) were performed 24 hours prior to the operation and repeated 1 hour and 6hours after the operation to evaluate the cognitive functions.
Interventions
Effect of ketamine use on postoperative cognitive dysfunction
(ketamin will be used, iv, 0.5 mg/kg, 5 minutes before induction.)
Sponsors
Necmettin Erbakan University Meram School of Medicine
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients aged 65 and older, who were at least literate, fell under the ASA I-II risk group
Exclusion criteria
Patients who had significant coronary, pulmonary, renal, hepatic diseases, neuropsychiatric diseases affecting the CNS and cognitive functions, fever and infection, metabolic and endocrinal diseases, malnutrition and dehydration, low levels of vitamin B12 and folate;those who took medications that affected CNS, who were alcohol and substance addicts, smokers, urgent cases, patients in the risk group of ASA III and above, patients younger than 65, those who scored 23 and lower in the SMMT (Standardized Mini Mental Test) performed one day before the operation were excluded from the study.
Outcome results
None listed