Salivary Cortisol in Women with Binge Eating Disorder

Will salivary cortisol reactivity change in response to visual stimuli in obese and non-obese women with Binge eating disorder?

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12616000209493

Enrollment

Registered

2016-02-16

Start date

2015-12-14

Completion date

2016-05-02

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Stress can cause episodes of binging in persons with binge eating disease (BED). People seeking treatment for obesity have 30% higher prevalence of BED. Stress elevates cortisol and persons with BED exposed to stress have exaggerated cortisol reactivity to stress. Elevated cortisol increases food intake and obesity risk. The objective of this controlled clinical trial is to determine salivary cortisol reactivity to visual stimuli in obese women with BED. The S-EDE-Q questionnaire will be used to diagnose BED, fat stigma and depression will be estimated by The Stigmatizing Situations Inventory and The Beck Depression Inventory respectively. Four groups will be stratified by the presence or not of obesity and by the presence or not of BED. All groups will participate in the intervention, a control video (7.5 minutes of neutral imagery) and an experimental video (7.5 minutes of highly caloric food). Salivary cortisol will be measured before, 15 minutes and 60 minutes after each video. We expect to see a higher reactivity of salivary cortisol to visual stimuli, higher levels of depression and fat stigma in subjects with BED.

Interventions

The visual stimuli experimental video will be shown to all subjects, on a single occasion, the experimental video will be 7.5 min of 15 static images of hypercaloric food

Study design

Allocation

Non-randomised trial

Intervention model

Parallel

Primary purpose

Diagnosis

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

Women between 18 and 55 years of age with BMI <35kg/m2 with and without binge eating disorder and women between 18 a 55 years of age with BMI >25kg/m2 with and without binge eating disorder.

Exclusion criteria

Bipolar disorder, obesive compulsive disorder, schizophrenia, cardiovascular disease, diabetes, cushing syndrome, use of any of these medications: steroids, hormonal contraceptives, antipsychotics, pregnancy, addiction to nicotine, alcohol and/or illegal drugs, menopause, weight loss of 20% or more of body weight.

Outcome results