None listed
Conditions
Brief summary
This will be a double-blind randomized trial. The participants will be supplemented with one of two different nutritional supplements and be submitted to resistance exercise training for 12 weeks. Participants will consume Whey Protein (25g) + Leucine (1.5g) or Whey protein (25g) + HMB (1.5g) twice a day. The primary purpose of this study is to: 1) Accurately evaluate the effect of Whey+HMB relative to Whey+Leucine in regards to muscle strength and size adaptation following resistance exercise training The secondary purpose of this study is to: 1) Quantitative evaluation the potential effect of HMB supplementation with resistance exercise on muscle power, total body mass, body fat mass, blood biochemistry, and muscle fiber cross-sectional area, as well as qualitative soreness/recovery status Hypothesis 1) We believe both groups will present the same changes during the training protocol.
Interventions
Self-administered oral whey protein with HMB (beta-hydroxy beta-methylbutyrate) supplementation (2 serves/day - 25g Whey/serve + 1.5g HMB/serve for 12 weeks)
To supervise adherence to this intervention, will have participants return empty supplement satchels weekly.
Researcher supervised resistance exercise training :
Phase 1: 3 sessions/week (Mondays, Wednesdays and Fridays) for weeks 1-8. Monday exercise routine: Squat, Bench Press, Deadlift, Pull Ups, Dips, Bent Over Row, Dumbbell Should
Self-administered oral whey protein with HMB (beta-hydroxy beta-methylbutyrate) supplementation (2 serves/day - 25g Whey/serve + 1.5g HMB/serve for 12 weeks) To supervise adherence to this intervention, will have participants return empty supplement satchels weekly. Researcher supervised resistance exercise training : Phase 1: 3 sessions/week (Mondays, Wednesdays and Fridays) for weeks 1-8. Monday exercise routine: Squat, Bench Press, Deadlift, Pull Ups, Dips, Bent Over Row, Dumbbell Shoulder Press, Barbell Curl, Skull Crushers (3 sets per exercise, 8-12RM (75% of 1RM), 60sec rest between sets). Wednesday exercise routine: Squat, Bench Press, Deadlift (5 sets per exercise, 5 maximal intended velocity repetition, 180sec rest between sets). Friday exercise routine: Squat, Bench Press, Pull Ups, Dips, Bent Over Row, Dumbbell Shoulder Press, Barbell Curl, Skull Crushers (3 sets per exercise, 3-5RM, 240sec rest between sets). Sessions will last Phase 2 (over-reaching): 6 sessions/week for weeks 9-10. Monday and Wednesday exercise routine: Squat, Bench Press, Deadlift, Pull Ups, Dips, Bent Over Row, Dumbbell Shoulder Press, Barbell Curl, Skull Crushers (3 sets per exercise, 8RM (75% of 1RM) on Monday and 12RM (65% of 1RM) on Wednesday, 60sec rest between sets. Tuesday and Thursday exercise routine: Leg Press, Bench Press, Military Press, Supinated Pull Ups, Dips, Bent Over Row, Dumbbell Shoulder Press, Hammer Curl, Close Grip Bench (3 sets per exercise, 8RM (75% of 1RM) on Tuesday and 12RM (65% of 1RM) on Thursday, 60 sec rest between sets. Friday exercise routine: Squat, Bench Press and Deadlift 1RM test, 3 Maximal attempts, 1RM load with 5min ret between sets. Saturday exercise routine: Wingate test (Cycloergometer 30sec peak power test). Phase 3 (taper): 3 sessions/week (Monday, Wednesday, Friday) of low intensity exercise for weeks 11-12. Exercise routine during week 11: Monday Friday - Squat, Bench Press and Deadlifts (5 sets, 5 repetition using maximal intended velocity, 180 rest, 40-60% 1RM). Monday - Squat, Bench Press, Deadlift, Pull Ups, Dips, Bent Over Row, Dumbbell Shoulder Press, Barbell Curl, Skull Crushers (1 sets per exercise, 3-5RM, >90%1RM, 240sec rest between sets). Exercise routine during week 12: Monday - Squat, Bench Press, Deadlift, Pull Ups, Dips, Bent Over Row, Dumbbell Shoulder Press, Barbell Curl, Skull Crushers (1 sets per exercise, 3-5RM, >90%1RM, 240sec rest between sets). Wednesday - Squat, Bench Press and Deadlifts (5 sets, 5 repetition using maximal intended velocity, 180 rest, 40-60% 1RM). Friday exercise routine: Squat, Bench Press and Deadlift 1RM test, 3 Maximal attempts, 1RM load with 5min ret between sets. Exercise sessions will be conducted individually, with each subject supervised by a research group member and will last 1-1.5h depending of the routine. Adherence will be monitored by register of attendance at scheduled sessions. Phone calls and text messages will be made to contact subjects that do not attend exercise sessions at scheduled times. If that is the case, the session will be re-schedule to another time on the same day.
Sponsors
Dr. Stuart Phillips
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
Male
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
1-Male 2-Aged 18-30 years old 3-Non-obese (Body mass index less than or equal to 30kg per square meter) 4-Non-smoker 5-Healthy based on questionnaire responses (see exclusion criteria) 6-Recreationally active (exercising ~2x/week) with some resistance training experience (no more than 2 times weekly) allowed.
Exclusion criteria
1-Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders–all ascertained through medical history screening questionnaires 2-Arthritic conditions 3-Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non-prescription, chronically will be excluded 4-A history of neuromuscular complications 5-Individuals on any medications known to affect protein metabolism (i.e. corticosteroides, non-steroidal anti-inflammatories, or prescription strength acne medications). 6-Extensive history of RE training in the year prior to study entry. 7-Answer ‘yes’ to any question on the PAR-Q Screening questionnaire
Outcome results
None listed