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Effect of Different Anesthesic Agents on Surgical Site Bleeding During Circumcisions

Effect of Different Anesthesic Agents ( ketamine+midazolam and propofol+fentanyl+lidocaine anesthesia) on Surgical Site Bleeding During Circumcisions

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12616000189426
Enrollment
100
Registered
2016-02-12
Start date
2014-10-13
Completion date
2014-12-29
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Objective: To investigate the effects of ketamine+midazolam and propofol+fentanyl+lidocaine anesthesia on surgical site bleeding during circumcision procedures. Materials and Methods: A total of 100 boys (aged 1-8 years) schedule for circumcision were included in the study. Patients were randomly divided into two groups. In the Group I (n=50), 0.01 mg/kg intravenous midazolam and 2 mg/kg intravenous ketamine were administered. In the Group II (n=50), 1microg/kg intravenous fentanyl, 1 mg/kg intravenous lidocaine, and 2-3 mg/kg intravenous propofol were administered and patency of airway was ensured with laryngeal mask airway. The intraoperative bleeding scale recorded during the procedure to evaluate surgical site bleeding. Dressing was checked to follow up bleeding throughout the postoperative. Results: Intraoperative bleeding scores were significantly higher in Group I as compared to Group IIduring circumcision procedures. However, there was no significant difference between the groups in amount of bleeding for postoperative period. Conclusion: Although intraoperative bleeding scores are significantly higher in ketamine+midazolamgroup compared to propofol+fentanyl+lidocaine group, this kind of bleeding can be easily controlled with appropriate hemostasis. Nevertheless ketamine should be carefully applied in patients with bleeding diathesis.

Interventions

A total of 100 boys (aged 1-8 years) schedule for circumcision were included in the study. Patients were randomly divided into two groups. In the Group I (n=50), 0.01 mg/kg intravenous midazolam and 2 mg/kg intravenous ketamine were administered only at induction of anaesthesia. In the Group II (n=50), 1 microg/kg intravenous fentanyl, 1 mg/kg intravenous lidocaine, and 2-3 mg/kg intravenous propofol were administered only at induction of anaesthesia and patency of airway was ensured with laryn

A total of 100 boys (aged 1-8 years) schedule for circumcision were included in the study. Patients were randomly divided into two groups. In the Group I (n=50), 0.01 mg/kg intravenous midazolam and 2 mg/kg intravenous ketamine were administered only at induction of anaesthesia. In the Group II (n=50), 1 microg/kg intravenous fentanyl, 1 mg/kg intravenous lidocaine, and 2-3 mg/kg intravenous propofol were administered only at induction of anaesthesia and patency of airway was ensured with laryngeal mask airway. The intraoperative bleeding scale recorded during the procedure to evaluate surgical site bleeding.

Sponsors

Derya Karasu
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
Male
Age
1 Years to 8 Years
Healthy volunteers
No

Inclusion criteria

- aged 1-8 years - who admitted to the hospital for circumcision - American Society of Anesthesiologists (ASA) physical status I-II

Exclusion criteria

- who showed contraindications (malignant hyperthermia history, toughness, etc.) under general anesthesia - who had history of allergy to anesthetic drugs - known bleeding diathesis; who indicated abnormalities in coagulation tests, - American Society of Anesthesiologists (ASA) physical status III-IV .

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 24, 2026