None listed
Conditions
Brief summary
Intravenous application of synthetic oxytocin after caesarean section delivery and umbilical cord transection is a common and widely accepted method for reducing postpartal bleeding and prevention of uterine atony. There are numerous clinical studies which have proven that after intravenous oxytocin application, due to the vasodilation effect, reducement in peripheral resistence occurs and mean arterial pressure (MAP) decreases. In response to those changes, compensatory tachycardia occurs and stroke volume of the heart increases. Although the impact of oxytocin on systemic circulation is known for decades, there is not much knowledge about the impact of oxytocin on lung haemodynamic and gas exchange. Due to our clinical observations, we decided to examine the impact of oxytocin on arterial oxygen saturation in caesarean section patients and to determine the possible difference in arterial oxygen saturation between general and spinal anaesthesia after intravenous application of oxytocin.
Interventions
Study involves patients scheduled for elective caesarean section under spinal (group 1) and general anaesthesia (group 2). All of the patients will be managed by the standard, routine spinal and general anaesthesia methods and will be monitored by the standard methods (pulse oximetry, ECG electrodes, non-invasive blood pressure). After clamping and cutting of the umbilical cord, 10 I.U. of synthetic oxytocin (the dose of oxytocin requested by the obstetrician due to the low uterine tone intraope
Study involves patients scheduled for elective caesarean section under spinal (group 1) and general anaesthesia (group 2). All of the patients will be managed by the standard, routine spinal and general anaesthesia methods and will be monitored by the standard methods (pulse oximetry, ECG electrodes, non-invasive blood pressure). After clamping and cutting of the umbilical cord, 10 I.U. of synthetic oxytocin (the dose of oxytocin requested by the obstetrician due to the low uterine tone intraoperatively) will be given intravenously as a bolus and 10 I.U. of oxytocin will be given as an infusion through 3 minutes in all of the patients. Any changes in oxygen saturation after intravenous application of oxytocin, as well as the changes in pulse and mean arterial pressure (MAP) will be recorded.
Sponsors
Obstetrics and Gynecology Clinic, Clinical Hospital Center Zagreb
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Patients scheduled for elective caesarean section
Exclusion criteria
Patients receiving standard doses of oxytocin (5 IU as a bolus plus 5 IU in infusion through 3 minutes) and patients receiving larger doses of oxytocin (>20 IU intraoperatively). Underlying lung disease (asthma, COPD) Preeclampsia, hypertension Intraoperative blood loss above 800 ml
Outcome results
None listed