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effect of lung recruitment after cardiac surgery of morbidly obese patients.

Respiratory failure after cardiac surgery of morbidly obese patients: effect of lung recruitment maneuvers after weaning from mechanical ventilation in intensive care unit.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12616000155493
Acronym
MRRea
Enrollment
194
Registered
2016-02-09
Start date
2016-02-11
Completion date
2017-12-22
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Obesity constantly increases in industrialized countries and is an independent risk factor for morbidity and mortality. After general anesthesia, particularly in patients with a BMI> 30, the occurrence of atelectasis, secondary to decreased lung compliance, vital capacity, increases the risk of acute respiratory failure (ARF). After a cardiac surgery, using extracorporeal circulation, the use of mammary arteries, phrenic nerve injury, pain, tracheal aspirations are additional risk factors to the occurrence of atelectasis and hypoxemia. The use of positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM) during mechanical ventilation are different methods used routinely in anesthesia and intensive care unit to reverse the hypoxemia caused by atelectasis. No randomized study has evaluated after cardiac surgery in patients with BMI > 30, the benefit of RM associated with PEEP on lowering occurrence of respiratory failure and the use of non- ventilation invasive, after weaning from mechanical ventilation. The main objective of the study is to evaluate the effect of maneuver recruitment and increasing PEEP on the incidence of respiratory distress syndrome after weaning from mechanical ventilation in obese patients after cardiac surgery.

Interventions

Lung atelectasis is frequently observed after open heart surgery. It may lead to hypoxemia, increased shunt fraction, and pulmonary complications in the postoperative period. Also during general anesthesia, as well as during the immediate postoperative period, obese patient are more likely than non obese patients to develop atelectasis. After cardiac surgery, patients are transfered in intensive care unit. Patients are ventilated with volume controlled ventilation by MAQUET Servo i respirator wh

Lung atelectasis is frequently observed after open heart surgery. It may lead to hypoxemia, increased shunt fraction, and pulmonary complications in the postoperative period. Also during general anesthesia, as well as during the immediate postoperative period, obese patient are more likely than non obese patients to develop atelectasis. After cardiac surgery, patients are transfered in intensive care unit. Patients are ventilated with volume controlled ventilation by MAQUET Servo i respirator which consisted of a tidal volume of 6-8 ml/kg and a positive end-expiratory pressure (PEEP) is applied at 5 cmH2O. PEEP is a pressure who is maintained within the airways during expiration at each expiratory cycle. It can be titrated from 0 to 20 cmH2O. This mechanical ventilation setting prevents the alveolar collapse formation at the end of expiration. The positive expiratory pressure also increases the time during which the gas exchange between alveolus and capillary occur. Sustainable maintenance of alveolar opening prevents the atelectasis formation. Also, in cardiac surgery and morbidly obese patients, recruitment maneuvers improves oxygenation. The main objective of the study is to evaluate the effect of maneuver recruitment and increasing PEEP on the incidence of respiratory distress after weaning from mechanical ventilation in obese patients after cardiac surgery. We chose to carry out the recruitment maneuver using pressure controlled ventilation (i MAQUET Servo ventilator) with inspiratory pressure at 30 cmH2O and PEEP at 15 cmH2O during 4 minutes In the hour following admission to intensive care, patients are randomized into 3 groups: 1/lack of recruitment maneuver and maintaining the initial ventilation (control group) 2/recruitment maneuver (RM) is applied with controlled pressure ventilation for 4 minutes then recovery to the initial ventilation. 5 cmH2O PEEP is continued during the mechanical ventilation with volume controlled ventilation after RM. 3/ recruitment maneuver is applied with controlled pressure ventilation for 4 minutes then recovery to the initial ventilation. 10 cmH2O is continued during the mechanical ventilation with volume controlled ventilation after RM. recruitment maneuver is carried out immediatly after randomisation.

Sponsors

Centre Chirurgical Marie Lannelongue
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

Morbidly obese patients with BMI>30 after cardiac surgery requiring mechanical ventilation in intensive care unit.

Exclusion criteria

Hemodynamic instability, PAM < 40 mmHg or PAS 20% decrease during recruitment maneuver oxygen saturation < 85% during recruitment maneuver

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026