None listed
Conditions
Brief summary
Stroke is a leading cause of long-term disability in many countries, causing both physical and cognitive problems. Patients who have recently suffered a transient ischaemic attack (TIA) event are particularly at risk of stroke. This study will investigate if a nitrate supplement can improve cerebrovascular health and enhance recovery from a TIA event, possibly lower risk factors which may lead to a later stroke. In human studies, dietary nitrate supplementation has been shown to lower blood pressure. Since high blood pressure is one of the main causes of stroke, dietary nitrate supplementation may reduce the risk of stroke in patients with TIA. Improving our understanding of the impact of the dietary supplementation on the cerebrovascular health of TIA patients would be an important step towards finding better treatments for TIA patients in New Zealand and elsewhere. We will test the hypothesis that dietary nitrate supplementation improves cerebrovascular health and blood pressure regulation in patients with TIA.
Interventions
7 day dietary sodium nitrate supplementation, 0.1mmol/kg/day (rounded to the nearest 60mg), administered in oral capsules (sodium nitrate, 60mg/capsule) across the meals (3 times daily). Adherence will be monitored by self-report, empty drug packet and assessment of pre and post blood plasma nitrate concentration.
Sponsors
Mickey Fan
Study design
Allocation
Randomised controlled trial
Intervention model
Other
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
20 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
Patient group 1) Those individuals aged 40-85 diagnosed as high risk TIA (with ABCD2 score greater than or equal to 4), after review by a specialist stroke physician 2) Those individuals living within Wellington City and the Greater Wellington region Healthy group 1) Healthy individuals (age 20-85 years) of both sex, specifically: 2) Free of history of long-term disease 3) Not currently taking any medication that may influence measures in this study. 4) Those individuals living within Wellington City and the Greater Wellington region
Exclusion criteria
Patient group 1) Those individuals requiring supplementary oxygen 2) Individuals with allergy to nitrates 3) Unstable cardiac conditions or angina 4) Uncontrolled diabetes mellitus 5) Major medical conditions 6) Significant cognitive impairment 7) Immobility Healthy group 1) Very high (greater than 140/90) or very low (lower than 100/60) resting blood pressure 2) Previous history of stroke, brain surgery, or severe head trauma 3) Pregnancy
Outcome results
None listed