None listed
Conditions
Brief summary
The primary aim of this study is to examine the association between the citrate concentration in haemofiltration fluid and the resulting Standard Base Excess (SBE) after several days of CVVHF. We expect to confirm that performing CVVHF using a relatively high citrate concentration HF (18.0mmol/l) results in an elevation of SBE. We expect to show that using a lower citrate concentration HF (15.0mmol/l) results in much less elevation of SBE. We also expect to show that use of the lower citrate concentration HF results in an acceptable filter life.
Interventions
Continuous veno-venous haemofiltration (CVVHF) using a new predilution haemofiltration solution containing 15mmol/L of trisodium citrate as the anticoagulant.
CVVHF is conducted routinely in the Intensive Care Unit (ICU) when patients with critical illness require kidney support. The treatment regime lasts, on average, about five days though there is considerable variation in length of treatment. The patients are usually simultaneously undergoing some type of ventilatory support.
Blood samples
Continuous veno-venous haemofiltration (CVVHF) using a new predilution haemofiltration solution containing 15mmol/L of trisodium citrate as the anticoagulant. CVVHF is conducted routinely in the Intensive Care Unit (ICU) when patients with critical illness require kidney support. The treatment regime lasts, on average, about five days though there is considerable variation in length of treatment. The patients are usually simultaneously undergoing some type of ventilatory support. Blood samples are routinely taken on at least a daily basis whilst the patients are receiving CVVHF. The occurrence of adverse events is monitored and if noted, dealt with in a timely and appropriate manner.
Sponsors
Nambour General Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Non-pregnant adult patients who require extracorporeal support for acute kidney failure while being treated in an intensive care unit (ICU).
Exclusion criteria
Age under 18 years. Pregnancy. Weight > 100kgs Advanced hepatic disease Predicted to die within 24 hours of admission to the ICU Allergy/hypersensitivity to citrate compounds.
Outcome results
None listed