comparison of magnesium sulfate and morphine sulfate in renal colic

In patients with renal colic, is magnesium sulfate more effective than morphine sulfate in relieving pain?

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12615001372572

Enrollment

Registered

2015-12-16

Start date

2015-11-01

Completion date

2015-12-30

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Renal colic due to renal stone is a most severe pain had been experienced, and is common cause of patient reference to health centers. Intravenous infusion of morphine sulfate is a common treatment, but its side effect is addiction. It has been mentioned that magnesium sulfate due to its calcium receptors antagonist effect and therefore muscle relaxation, was a pain relief especially in migraine headache. this study compares effectiveness and side effects of intravenous infusion of morphine sulfate and magnesium sulfate in renal colic patient who were referred to shahid sadoughi educational hospital. This paper is double-blinded randomized control trial study. Eighty patients with renal colic divided in two groups: case group took 50 mg/kg intravenous infusion and the control group took morphine sulfate 0.1 mg/kg intravenous infusion.pain score and probable side effects( such as vomiting, nausea, low blood pressure, apnea and dizziness) during zero, 15 and 30 minutes after infusion in both group recorded by a blinded person, and data analyzed by SPSS software.

Interventions

First 5 ml distilled water intravenous injection, then 50 mg per kg of weight magnesium sulfate in 100 ml normal saline intravenous infusion in 20 minutes, single dose only.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Healthy volunteers

Inclusion criteria

patients with renal colic with age of 18-55 years

Exclusion criteria

renal failure, pregnancy, systolic blood pressure under 100mmhg, respiratory rate under 12 per minute, opium addict, heart failure, patients that are under treatment with magnesium sulfate

Outcome results