None listed
Conditions
Brief summary
Supervised, group-based computerised cognitive training (CCT) is a safe and effective intervention to maintain cognition in healthy older adults. This study will examine the extent to which CCT can attenuate or even reverse the rate of decline in older people with previously documented cognitive decline, as well as strategies to maintain CCT effects in the long term.
Interventions
Supervised multi-domain computerised cognitive training using Captain's Log MindPower Builder. There will be small group training sessions with a maximum of 8 participants per session and two supervisors. One of the supervisors has a background in conducting clinical trials with Computerised Cognitive Training and the other supervisor will be a clinical neuropsychologist.
There will be an attendance log kept by the supervisor and there is also a computer login date and time recorded per partici
Supervised multi-domain computerised cognitive training using Captain's Log MindPower Builder. There will be small group training sessions with a maximum of 8 participants per session and two supervisors. One of the supervisors has a background in conducting clinical trials with Computerised Cognitive Training and the other supervisor will be a clinical neuropsychologist. There will be an attendance log kept by the supervisor and there is also a computer login date and time recorded per participant. In months 1-3, participants undergo 24 training sessions (2 sessions per week, 60 minutes per session for 12 weeks). In months 4-18, participants will be asked to complete a 60-minute booster session every month. Participants whose within-session performance on one or more cognitive exercises falls to below 15% of their post-training maxima will be invited to attend three additional 60-minute booster sessions the following week.
Sponsors
University of Sydney
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Older adults (aged 60 years or older) with documented longitudinal cognitive decline unresponsive to intervention (not attributable by illness or new medication onset): those individuals who, over the course of at least 6-24 months and multiple neuropsychological assessments have had any memory-related test decline by at least 0.5SD of age-corrected norms despite routine clinic intervention. Memory tests administered by the clinics include: WMS-III Logical memory (I and II), the RAVLT and the Rey Complex Figure.
Exclusion criteria
(1) history, diagnosis or treatment for dementia (of any aetiology); (2) current use of third-generation or tricyclic antidepressants; (3) history of stroke in last 12 months; (4) major neurological disorder requiring current treatment (epilepsy, Parkinson's disease); (5) major psychiatric disorder requiring current treatment (schizophrenia, bipolar disorder); (6) physical (sensory or motor) impairment that would limit training; (7) current undertaking of any other computerised cognitive training (CCT) program; (8) current alcohol dependence or abuse (defined as drinking over NHMRC guidelines); (9) definitive exclusion of possible undiagnosed major depression using the Geriatric Depression Scale (15-item score 10 or greater) or Hamilton Rating Scale for Depression (17-item score 12 or greater) i.e. if participants were found to have clinical depression scores at baseline measurement that were not previously diagnosed, these participants will be excluded.
Outcome results
None listed