None listed
Conditions
Brief summary
Critical ill patients loose lean body and muscle mass at a high rate. This fast wasting is related to a worsened clinical outcome. Appropriate protein feeding might prevent or reduce the wasting and thereby affect outcome. However, the best amount of protein for this is not well characterized. In a previous study we have shown that an 3 hour parenteral supplementation of amino acid to these patients results in a positive protein balance and that the extra amino acids are not oxidizes (Liebau et al. Crit Care 2015, 19:106.). The aim of the present study is to investigate if this effect persists over a longer time and therefore measurements of protein balance and oxidation are performed during 24 hours of supplementation after both 3 and 24 hours.
Interventions
Critical patients treated in a medical/surgical ICU or intermediary unit will receive supplemental parenteral amino acids in addition to their ongoing nutrition. The supplemental amino acids will be given as an equivalent of 1 gram protein/kg body weight per day for 24 hours. A mixture of amino acids (Glavamin, Fresenius) will be infused at a continuous rate of 0.083 g/kg/h for 24 hours. Infusion rates for the supplement will be automatically registered in the on-line clinical management system
Critical patients treated in a medical/surgical ICU or intermediary unit will receive supplemental parenteral amino acids in addition to their ongoing nutrition. The supplemental amino acids will be given as an equivalent of 1 gram protein/kg body weight per day for 24 hours. A mixture of amino acids (Glavamin, Fresenius) will be infused at a continuous rate of 0.083 g/kg/h for 24 hours. Infusion rates for the supplement will be automatically registered in the on-line clinical management system (ClinSoft). Measurements of whole-body protein kinetics is performed just before supplementation and at 3 and 24 hours after start of the supplementation.
Sponsors
Olav Rooyackers
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Critically ill patients with expected stable nutrition for 30 hours.
Exclusion criteria
Ongoing dialysis
Outcome results
None listed