None listed
Conditions
Brief summary
Recent research has shown Kyolic aged garlic extract to improve cardiovascular function, including peripheral and central blood pressure and arterial stiffness. Arterial stiffness is inversely correlated to aerobic capacity. Additionally, animal and clinical data have linked aged garlic extract to ameliorate physical fatigue, increase exercise tolerance and increased oxygen uptake. This study aims to investigate the effect of 3-month supplementation of aged garlic extract compared to placebo on arterial stiffness and aerobic fitness measured by oxygen uptake, lactate levels and muscle fatigue (as 'lactate to rated perceived exertion (RPE) ratio), in a group of sedentary adults during moderate intensity exercise.
Interventions
This randomised double-blind placebo-controlled trial of 12 weeks will examine the effect of aged garlic extract on aerobic capacity during moderate intensity exercise, measured by predicted VO2max, and arterial stiffness, indicated by pulse wave velocity and augmentation pressure, in a group of sedentary adults, compared with placebo. The active treatment group will be allocated to two daily capsules of aged garlic extract (1.2 g Kyolic Reserve, 1.2 mg S-allylcysteine (SAC)).
Compliance will
This randomised double-blind placebo-controlled trial of 12 weeks will examine the effect of aged garlic extract on aerobic capacity during moderate intensity exercise, measured by predicted VO2max, and arterial stiffness, indicated by pulse wave velocity and augmentation pressure, in a group of sedentary adults, compared with placebo. The active treatment group will be allocated to two daily capsules of aged garlic extract (1.2 g Kyolic Reserve, 1.2 mg S-allylcysteine (SAC)). Compliance will be assessed by return of trial capsules, as well as diary entries. Patients will be instructed to mark each day in provided calendars when they have taken the trial and prescription medications, and bring the calendar and the remaining trial medication to their next appointment.
Sponsors
National Institute of Integrative Medicine
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1) International physical activity questionnaire (IPAQ) score of 2 or below (minimally active) 2) Elevated pulse wave velocity and / or augmentation pressure (higher half of reference values, adjusted for age and gender) (Nunan 2012; Nunan 2014)
Exclusion criteria
1) IPAQ score greater than 3 2) Unstable medical condition or serious illness, at the discretion of their GP (did not pass adult pre-exercise screening tool (AFIRM) 3) Pregnancy 4) Poor comprehension of written or spoken English 5) Currently taking daily garlic supplements
Outcome results
None listed