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Evaluation of postoperative pain scores with deep versus moderate neuromuscular blockade during laparoscopic cholecystectomy.

In patients undergoing laparoscopic cholecystectomy, what is the effect of deep versus moderate muscle blockade on postoperative pain scores?

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12615001297516
Enrollment
50
Registered
2015-11-27
Start date
2014-12-01
Completion date
2015-05-31
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We assessed the postoperative pain scores with 11 point numeric rating scale for deep and moderate muscle blockade after laparoscopic cholecystectomy. In addition we assessed the surgical space conditions during surgery with 4-point scale and numeric rating scale.

Interventions

Group 1: Deep neuromuscular blockade with bolus intraveneous 1 mg/kg rocuronium for 8 mmHg intraabdominal pressure for pneumoperitoneum at the beginning of the procedure. 5% carbon dioxide (CO2) at 37 degrees Celsius and 50% humidity was used for pneumoperitoneum from time of incision to time of closure of the abdomen. 0.1-0.2 mg/kg rocuronium was administered multiple doses at clinical discretion of anaesthetist to maintain deep neuromuscular blockade during surgery if post-tetanic count >1. Gr

Group 1: Deep neuromuscular blockade with bolus intraveneous 1 mg/kg rocuronium for 8 mmHg intraabdominal pressure for pneumoperitoneum at the beginning of the procedure. 5% carbon dioxide (CO2) at 37 degrees Celsius and 50% humidity was used for pneumoperitoneum from time of incision to time of closure of the abdomen. 0.1-0.2 mg/kg rocuronium was administered multiple doses at clinical discretion of anaesthetist to maintain deep neuromuscular blockade during surgery if post-tetanic count >1. Group 2: moderate neuromuscular blockade with bolus intraveneous 0.5 mg/kg rocuronium for 12 mmHg intraabdominal pressure for pneumoperitoneum at the beginning of the procedure. 5% carbon dioxide (CO2) at 37 degrees Celsius and 50% humidity was used for pneumoperitoneum from time of incision to time of closure of the abdomen. No further rocuronium was administered for moderate blockade.

Sponsors

Istanbul training and research hospital
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

ASA(American Society of Anesthesiologists) 1-2 Patients Undergo laparoscopic cholecystectomy

Exclusion criteria

Body Mass Index greater than 35 Body Mass Index less than 18 Neurological Disorders Coagulopathy Allergic to narcotic and NSAID agents Cancer patients Chronic Pain Disorders

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026