Fluid therapy to prevent hypotension in patients having colonoscopy

The effect of two volumes of intravenous Plasma-Lyte 148 (20 mL/Kg and 2 mL/kg) on the incidence of a decrease in systolic blood pressure of greater than or equal to 25% from baseline during intravenous sedation for elective colonoscopy in adult patients.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12615001288516

Enrollment

150

Registered

2015-11-26

Start date

2015-03-23

Completion date

2015-09-02

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Colonoscopy is one of the most common medical procedures performed in Australia. Patients having colonoscopy take oral bowel preparation and fast before their procedure. During their procedure they receive sedative drugs. All these factors can cause low blood pressure during the procedure. In addition they can be associated with nausea, vomiting, headache, dizziness, drowsiness, thirst and low satisfaction with care after the procedure. We are testing whether a high volume (2o mL/kg) of a balanced salt solution given intravenously before the procedure will prevent low blood pressure and unwanted postoperative symptoms when compared with a low volume (2 mL/kg) of the same solution. We are testing this in adult patients presenting for elective colonoscopy at our hospital.

Interventions

Intravenous Plasma-Lyte 148 20 mL/kg administered before sedation for elective colonoscopy

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Presenting for elective colonoscopy with or without gastroscopy Successful oral bowel preparation Planned intravenous sedation by an anaesthetist Able to communicate in English No prior intravenous fluid administration No planned intravenous fluid administration No contraindication to intravenous fluid administration (e.g. uncontrolled heart failure or end-stage renal failure)

Exclusion criteria

Presenting for emergency colonoscopy Unsuccessful oral bowel preparation Planned intravenous sedation by a non-anaesthetist Unable to communicate in English Prior intravenous fluid administration Planned intravenous fluid administration Contraindication to intravenous fluid administration (e.g. uncontrolled heart failure or end-stage renal failure)

Outcome results