Can Phytochemicals Alter Intestinal Carbohydrate Digestion in Ileostomates

Phytochemicals and carbohydrate digestion in ileostomates as measured by ileal carbohydrate excretion

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12615001263583

Enrollment

Registered

2015-11-19

Start date

2015-11-13

Completion date

2015-12-21

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The objective of the study is to determine whether consumption of sugar cane molasses extract (SCE) reduces dietary carbohydrate absorption from the small intestine

Interventions

Participants will adhere to a low starch and sucrose dietary pattern for 4 days (Monday-Thursday) as set by the research dietitian; with the exception of a daily high starch/high sucrose breakfast test meal. Monday is a planned run in day and Wednesday a washout day. On Tuesday and Thursday participants will be randomised to consume one of two test drinks with the breakfast meal. Drinks are identical with the exception of one containing a phytonutrient rich sugar cane molasses extract, made up in water to a volume of 355mL. Dietary compliance is assessed by dietary records. Ileal efflux is collected at regular intervals (2 hourly; 07:00-23:00) for the duration of the study to measure carbohydrate excretion.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

minimal terminal ileum removed

Exclusion criteria

History of drug or alcohol abuse Participation in a study within 30 days of commencement of the present study. Use of any medication or supplement that may, in the opinion of the Principal Investigator, interfere with the study or small intestinal function. Definite or suspected personal or family history of intolerance or adverse events following consumption of foods which may be tested in this study. Person considered, in the opinion of the Principle Investigator, to be unwilling, unlikely or unable to comprehend or comply with the study protocol. Unwilling or unable to collect ileal effluent as required.

Outcome results