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Magnesium supplementation and Deoxyribonucleic acid (DNA) oxidative damage

Role of magnesium in maintaining DNA integrity after oxidative challenge "in vitro" in healthy young men

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12615001237572
Acronym
MSDOD
Enrollment
23
Registered
2015-11-11
Start date
2013-09-01
Completion date
2013-09-02
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In the study 13 rugby players and 10 university students with sedentary life-style were involved. They were randomly assigned to intervention of supplementation with magnesium for 28 days. On the 29th day blood samples were taken and in peripheral blood lymphocytes, by using alkaline comet test, the level of DNA damage was examined.

Interventions

Supplementation with magnesium 28 days, oral tablets 250 mg, 2 times daily. Text message will be sent at the time for administration and Mg tablets will be returned after intervention. Participants will NOT undergo oxidative challenge, but participants will give blood samples so that their peripheral blood lymphocytes can be evaluated in an "in vitro" test with the hydrogen-peroxide solution.

Sponsors

University of Belgrade
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
Male
Age
18 Years to 25 Years
Healthy volunteers
Yes

Inclusion criteria

Young man (18-25 years old) athletes or sedentary

Exclusion criteria

any inflamation, chronic illness, using supplements

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 2, 2026