None listed
Conditions
Brief summary
Patients who present with an acute coronary syndrome remain at high risk of further events in subsequent years. Better identification of individuals at high risk can allow better targeting of novel therapies and resources. This study will create an imaging bio-bank that enables testing of multiple novel strategies involving new imaging, image analysis and biomarker approaches alone or in combination for improved risk stratification and targeting of prevention. Prospective follow-up in the cohort for outcomes enables the predictive value to be tested in a pilot data setting.
Interventions
High resolution catheter based laser imaging using optical coherence tomography (OCT) is used during coronary angiography. It is a routine procedure used in select patients (at the Cardiologists discretion) to view high resolution images from inside the blood vessels. The OCT imaging will add 10- 15 minutes to the angiogram procedure.
A functional PET scan that detects the activity of coronary calcium build-up will take approximately 30 minutes. It is not a routine procedure.
Blood samples wil
High resolution catheter based laser imaging using optical coherence tomography (OCT) is used during coronary angiography. It is a routine procedure used in select patients (at the Cardiologists discretion) to view high resolution images from inside the blood vessels. The OCT imaging will add 10- 15 minutes to the angiogram procedure. A functional PET scan that detects the activity of coronary calcium build-up will take approximately 30 minutes. It is not a routine procedure. Blood samples will be taken at the baseline assessment (once consent is given) and stored to establish a bio-bank. The samples will be used investigate how fast atherosclerosis and calcium build-up occurs in the coronary arteries. A CT-scan that determines 3-dimensional trajectory for calculation of stress distribution on artery walls is a commonly used imaging modality in patients. This scan also takes approximately 30 minutes.
Sponsors
University of Western Australia
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 80 No limit
Healthy volunteers
No
Inclusion criteria
Patients presenting to hospital with: NSTEMI proceeding to in-patient angiography STEMI proceeding to non-emergency in-patient angiography (late presentation or reperfused without PCI) All major epicardial coronary arteries suitable for for OCT prior to stenting (intervention). The time point is during that hospital admission for the MI event. Simply in-patient angiography.
Exclusion criteria
eGFR <40ml/min with diabetes mellitus unlikely to survive for at least 3 years due to a co-morbidity coronary anatomy unsuitable for OCT pregnancy prior coronary Bypass Graft STEMI treated with PCI.
Outcome results
None listed