None listed
Conditions
Brief summary
The aim of the study is to determine the effects of red grape extract (RGE) in breakfast beverages on subjective appetite and blood glucose responses. We hypothesise that RGE increases satiety effect of the beverage through the strong GLUT2 transporter inhibitor thus eliciting an ileal brake effect by inhibiting the uptake of glucose, which is measured by blood glucose concentrations.
Interventions
The potential satiety ingredient, Oxifend Red Grape Extract (RGE) is sourced from New Zealand Extracts Ltd. The aim of this study is to compare 3 formulated beverages, without RGE (control), with low dose RGE (1.25g in 250mL serve) and with high dose RGE (2.5g in 250mL serve), on subjective appetite and blood glucose responses when consumed and over 4 hours. The study design will be double-blinded, placebo controlled, crossover, randomised and completely balanced. Participants will be randomised
The potential satiety ingredient, Oxifend Red Grape Extract (RGE) is sourced from New Zealand Extracts Ltd. The aim of this study is to compare 3 formulated beverages, without RGE (control), with low dose RGE (1.25g in 250mL serve) and with high dose RGE (2.5g in 250mL serve), on subjective appetite and blood glucose responses when consumed and over 4 hours. The study design will be double-blinded, placebo controlled, crossover, randomised and completely balanced. Participants will be randomised to consume the 3 formulated beverages (each beverage once during a single morning, taken 30 minutes before standard breakfast), with a washout period of 3 days to 1 week between beverages. The standard breakfast meals will be provided to the participants, which comprises of 60g Sanitarium toasted muesli and 150 ml skim milk. The sessions will be held at the Human Clinical Facility at Plant & Food Research, Palmerston North (meeting room), where participants will be comfortably seated and could bring their work or reading material to the sessions. The study investigators will be administering the intervention, who are also trained to collect finger-prick blood samples for glucose measurements. We have detailed procedures in place to ensure adherence to the intervention. Participants are provided with the study information sheet and requirements (e.g. fasting from 10pm onwards on days before each session) and procedures explained to them during face-to-face meeting.
Sponsors
The New Zealand Institute for Plant & Food Research Ltd
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy male and female individuals, aged 18–60 years with BMI of 18.5–26 kg/m2 (or up to 30 kg/m2 if healthy, by self-report)
Exclusion criteria
Pregnant women, smokers, on medication, on restrained diet, have food allergy or intolerance to soy, milk, cereals (gluten), nuts, sesame seeds.
Outcome results
None listed